Branson D F, Picha G J, Desprez J
Plast Reconstr Surg. 1985 Nov;76(5):754-63. doi: 10.1097/00006534-198511000-00017.
The utility for a prosthetic microvascular graft is well demonstrated, but previous studies have been inconclusive. Expanded polytetrafluoroethylene (Gore-Tex) has been most widely tested as a prosthetic graft. Polytetrafluoroethylene is composed of transverse nodules connected by long fibrils. This study evaluates the effect of fibril length on observed patency in a 1-mm inner-diameter system. Fibril lengths tested were 30, 60, 90, and 120 micron. One-hundred and sixty-three grafts were implanted in the abdominal aorta of Sprague-Dawley rats by a single surgeon using a standardized technique. No anticoagulants were used. Grafts were harvested at predetermined times and evaluated macroscopically, by scanning electron microscope, and by standard histology. The highest patency observed was 97.7 percent in the 90-micron fibril-length grafts. Fibril morphology also affected patency. Increased patency was associated with an amorphous fibril pattern. The graft functioned as a matrix for the formation of a pseudoartery, complete with monocell-thick intima and smooth-muscle media. A foreign-body reaction was observed in the 60-micron fibril-length graft only. Expanded polytetrafluoroethylene does show promise as a microvascular graft. Both fibril length and morphology affect observed patency.
人工微血管移植物的效用已得到充分证明，但先前的研究尚无定论。膨体聚四氟乙烯（戈尔特斯）作为人工移植物已得到最广泛的测试。聚四氟乙烯由通过长纤维连接的横向结节组成。本研究评估了纤维长度对内径为1毫米系统中观察到的通畅率的影响。测试的纤维长度为30、60、90和120微米。一位外科医生使用标准化技术将163个移植物植入斯普拉格-道利大鼠的腹主动脉。未使用抗凝剂。在预定时间采集移植物，并通过肉眼、扫描电子显微镜和标准组织学进行评估。在90微米纤维长度的移植物中观察到的最高通畅率为97.7%。纤维形态也影响通畅率。通畅率的提高与无定形纤维模式有关。该移植物起到了形成假动脉的基质的作用，具有单层细胞厚的内膜和平滑肌中膜。仅在60微米纤维长度的移植物中观察到异物反应。膨体聚四氟乙烯作为微血管移植物确实显示出前景。纤维长度和形态均会影响观察到的通畅率。
