O'Brien C J, Wilson E A, Velkou D, Harris J P, May J
Plast Reconstr Surg. 1985 Nov;76(5):748-53. doi: 10.1097/00006534-198511000-00015.
The efficacy of 1-mm internal-diameter polytetrafluoroethylene as a microvascular prosthesis is unclear. In this study, 8-mm-long segments of this material were implanted into the femoral arteries of 30 rats. Animals were examined every 2 weeks up to 6 months by Doppler ultrasound. Cumulative patency by the life-table method was 86.7 percent at 6 months. There were 26 patent grafts, 2 occlusions, and 2 deaths. Intimal hyperplasia adjacent to the anastomoses was seen in the native arteries. The pseudointima lining the grafts was cellular near the anastomoses but usually acellular in midgraft regions. It is concluded that if early failure does not occur, then good long-term patency is possible with 1-mm polytetrafluoroethylene in this setting and that patency is not dependent on development of a cellular pseudointima. Longer graft segments should be evaluated in future studies.
内径为1毫米的聚四氟乙烯作为微血管替代物的疗效尚不清楚。在本研究中，将8毫米长的该材料段植入30只大鼠的股动脉。每隔2周对动物进行检查，直至6个月，采用多普勒超声进行检测。通过寿命表法计算，6个月时的累积通畅率为86.7%。有26个移植血管通畅，2个闭塞，2只大鼠死亡。在天然动脉中可见吻合口附近的内膜增生。移植血管内衬的假内膜在吻合口附近有细胞成分，但在移植血管中段通常无细胞成分。得出的结论是，如果不发生早期失败，那么在这种情况下，1毫米聚四氟乙烯可能具有良好的长期通畅率，且通畅率不依赖于细胞性假内膜的形成。未来的研究应评估更长的移植血管段。
