Wu Nan, Zhi Leilei, Wang Gaixiang, Liu Yu, Feng Jun, You Bing
R&D Centre, PeiLai Brand Management Co., Ltd., Building A, Noah Wealth Centre, No.1226 Shenbin South Road, Minhang District, Shanghai, 201106, China.
Shanghai WEIPU Testing Technology Group Co., Ltd, No.9 Building, No.135 Guowei Road, Yangpu District, Shanghai, 200438, China.
Sci Rep. 2025 Jul 1;15(1):22175. doi: 10.1038/s41598-025-06571-z.
Human hair is a biopolymer composed of keratin filaments, lipids, pigments, and water. Chemical treatments of hair, such as dyeing, perming, and bleaching, can impair the integrity of the hair protein structure and accelerate the loss of water and lipids, resulting in increased fragility, breakage, and rapid colour fading. This study investigates compositional changes in fermented grapeseed oil (F-GO) compared to grapeseed oil (GO) and identifies its enhanced hair permeability, highlighting its substantial potential to mitigate hair damage from bleaching and dyeing. The fluorescent labelling results verified that the ability to permeate hair was significantly improved by F-GO compared to GO and silicone oil. Fourier transform infrared spectroscopy (FT-IR) and thermal weight analyser (TGA) results illustrate that F-GO-treated hair can form additional intermolecular hydrogen bonds and might cause a conformational change in the protein structure. The in vitro assessments demonstrate that F-GO delays hair colour loss and enhances mechanical properties. The colour fixation mechanism of F-GO is attributed to its ability to act as an anti-oxygen barrier on the outer layer and a lipid barrier in the inner layer. Together, they protect against pigment loss and degradation. F-GO enhances damaged hair strength by forming hydrogen bonds with keratin residues and preserving lipids and moisture contents. Therefore, F-GO has broad application prospects for bleaching and dyeing damaged hair improvement.
人类头发是一种由角蛋白丝、脂质、色素和水组成的生物聚合物。对头发进行化学处理，如染发、烫发和漂白，会损害头发蛋白质结构的完整性，加速水分和脂质的流失，导致头发更加脆弱、易断裂和快速褪色。本研究调查了发酵葡萄籽油（F-GO）与葡萄籽油（GO）相比的成分变化，并确定了其增强的头发渗透性，突出了其减轻染发和漂白对头发损伤的巨大潜力。荧光标记结果证实，与GO和硅油相比，F-GO显著提高了渗透头发的能力。傅里叶变换红外光谱（FT-IR）和热重分析仪（TGA）结果表明，经F-GO处理的头发可以形成额外的分子间氢键，并可能导致蛋白质结构的构象变化。体外评估表明，F-GO可延缓头发褪色并增强机械性能。F-GO的固色机制归因于其在外层作为抗氧化屏障和在内层作为脂质屏障的能力。它们共同防止色素损失和降解。F-GO通过与角蛋白残基形成氢键并保持脂质和水分含量来增强受损头发的强度。因此，F-GO在改善染发和漂白受损头发方面具有广阔的应用前景。
