Yang Huan, Lu Haoyu, Xue Chen, Lin Liangjie, Wang Cuiyan, Wang Ximing, Yang Guiwen, Yin Qingqing, Liu Bo
Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, Shandong, China.
Sci Rep. 2025 Jul 2;15(1):22689. doi: 10.1038/s41598-025-07229-6.
Our study aimed to explore the calcification patterns of culprit lesions associated with artery-to-artery embolism (AAE) infarction in patients with vertebrobasilar artery atherosclerosis, using vessel wall magnetic resonance imaging (VW-MRI) and computed tomography (CT). We retrospectively analyzed data from patients undergoing VW-MRI and CT scans at two institutions. Patients with ≥ 50% vertebrobasilar atherosclerotic stenosis were categorized based on their stroke mechanisms as AAE (+) and AAE (-). Calcification profiles of the culprit lesion, including the morphology, location, quantity, and VW-MRI characteristics were compared among stroke patients. Multivariate logistic regression model was used to evaluate the relationship between vertebrobasilar artery calcification characteristics and the presence of AAE (+). Among the 151 stroke patients included, 56 (37.09%) were classified as AAE (+), while 95 (62.91%) as AAE (-). Multivariate regression analysis revealed the odds ratio of AAE (+) was 2.69 and 2.15 for the presence and count of spotty calcification, 3.33 for intimal-predominant calcification, and 3.65 for multiple calcifications. Calcification characteristics observed at the culprit lesion were associated with posterior circulation infarction in patients exhibiting AAE infarction. Understanding the relationship between intracranial artery calcification and stroke mechanisms may help clinicians improve stroke prevention and treatment.
我们的研究旨在利用血管壁磁共振成像（VW-MRI）和计算机断层扫描（CT），探索椎基底动脉粥样硬化患者中与动脉到动脉栓塞（AAE）梗死相关的罪犯病变的钙化模式。我们回顾性分析了两家机构接受VW-MRI和CT扫描的患者的数据。椎基底动脉粥样硬化狭窄≥50%的患者根据其卒中机制分为AAE（+）组和AAE（-）组。比较了卒中患者罪犯病变的钙化特征，包括形态、位置、数量和VW-MRI特征。采用多因素逻辑回归模型评估椎基底动脉钙化特征与AAE（+）存在之间的关系。在纳入的151例卒中患者中，56例（37.09%）被分类为AAE（+），而95例（62.91%）为AAE（-）。多因素回归分析显示，点状钙化的存在和计数的AAE（+）比值比分别为2.69和2.15，内膜为主型钙化的比值比为3.33，多发钙化的比值比为3.65。在表现为AAE梗死的患者中，罪犯病变处观察到的钙化特征与后循环梗死相关。了解颅内动脉钙化与卒中机制之间的关系可能有助于临床医生改善卒中的预防和治疗。
