Jennings J R, Follansbee W P
Psychosom Med. 1985 Sep-Oct;47(5):415-30. doi: 10.1097/00006842-198509000-00002.
The relationship between psychologically induced autonomic responses, ST segment depression, and ectopy was examined in patients with coronary artery disease (CAD) and controls. Both groups underwent a battery of performance tasks and interviews. Performance tasks were selected to yield predictable sympathetic and vagal responses. Autonomic activation in response to stimuli was documented using heart rate, blood pressure, and vascular indices. ST segment depression was observed in a significant portion of the sample. In subjects with CAD, ST segment depression, but not ectopy, was specifically associated with mental arithmetic. In this task, autonomic changes occurred, suggesting beta sympathetic activation. The prevalence of ST segment depression during mental arithmetic declined when a task-inducing brief, phasic vagal activation was combined with the mental arithmetic. Ectopic beats were not associated with a specific task among either patients or controls. The results supported the importance of psychologically induced autonomic response for the precipitation and inhibition of ST segment depression in patients with CAD.
在冠心病（CAD）患者和对照组中，研究了心理诱导的自主神经反应、ST段压低和异位心律之间的关系。两组均接受了一系列的操作任务和访谈。选择操作任务以产生可预测的交感神经和迷走神经反应。使用心率、血压和血管指数记录对刺激的自主神经激活情况。在相当一部分样本中观察到ST段压低。在CAD患者中，ST段压低而非异位心律与心算特别相关。在这项任务中，出现了自主神经变化，提示β交感神经激活。当一项诱导短暂、阶段性迷走神经激活的任务与心算相结合时，心算期间ST段压低的发生率下降。在患者或对照组中，异位搏动均与特定任务无关。结果支持了心理诱导的自主神经反应对CAD患者ST段压低的诱发和抑制的重要性。
