Yang Yingrui, Pei Xiaoting, Sun Jiali, Xia Mengting, Tian Lina, Kang Yanxia, Li Zhijie
Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People's Hospital, Henan Eye Institute, People's Hospital of Zhengzhou University, Zhengzhou City, 450003, Henan Province, China.
Sci Rep. 2025 Jul 1;15(1):20566. doi: 10.1038/s41598-025-06641-2.
Diabetes mellitus (DM) is a major global health concern associated with complications that significantly impair quality of life. Among these, the impact of DM on visual function and the underlying mechanisms, particularly the role of sleep quality, remain insufficiently understood. This cross-sectional study recruited 629 participants from Henan Provincial People's Hospital to examine the relationships among DM, sleep quality, and visual function. Visual function was assessed using the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25), while sleep quality was evaluated with the Pittsburgh Sleep Quality Index (PSQI). Compared to non-diabetic controls, individuals with DM exhibited significantly poorer visual function and sleep quality. Path analysis further revealed that sleep quality played a significant mediating role in the relationship between DM and visual function, accounting for 42.2% of the total effect. Subgroup analyses indicated that female and elderly patients with DM were more susceptible to the influence of sleep disturbances on visual outcomes. These findings underscore the critical role of sleep quality in diabetes-related visual impairment and highlight the importance of incorporating routine sleep assessments and targeted interventions into diabetes management to help preserve visual function and improve overall quality of life in diabetic populations.
糖尿病（DM）是一个重大的全球健康问题，其并发症会严重损害生活质量。其中，糖尿病对视觉功能的影响及其潜在机制，尤其是睡眠质量的作用，仍未得到充分了解。这项横断面研究从河南省人民医院招募了629名参与者，以研究糖尿病、睡眠质量和视觉功能之间的关系。使用美国国立眼科研究所视觉功能问卷25项（NEI-VFQ-25）评估视觉功能，同时用匹兹堡睡眠质量指数（PSQI）评估睡眠质量。与非糖尿病对照组相比，糖尿病患者的视觉功能和睡眠质量明显更差。路径分析进一步表明，睡眠质量在糖尿病与视觉功能的关系中起显著中介作用，占总效应的42.2%。亚组分析表明，女性和老年糖尿病患者更容易受到睡眠障碍对视觉结果的影响。这些发现强调了睡眠质量在糖尿病相关视力损害中的关键作用，并突出了将常规睡眠评估和针对性干预纳入糖尿病管理以帮助保护糖尿病患者视觉功能和提高整体生活质量的重要性。
