School of Basic Medical Sciences, Xi'an Medical University, Xi'an, China.
Department of Ophthalmology, Shaanxi Provincial People's Hospital, Xi'an, China.
BMC Ophthalmol. 2023 Sep 11;23(1):372. doi: 10.1186/s12886-023-03118-6.
Diabetic retinopathy is one of the most common and serious microvascular complications of diabetes mellitus. There are many factors leading to diabetic retinopathy, and its pathogenesis is still unclear. At present, there are still no effective measures for the early treatment of diabetic retinopathy, and the treatment options available when diabetes progresses to advanced stages are very limited, and the treatment results are often unsatisfactory. Detailed studies on the molecular mechanisms of diabetic retinopathy pathogenesis and the development of new therapeutic agents are of great importance. This review describes the potential pathogenesis of diabetic retinopathy for experimental studies and clinical practice.
糖尿病视网膜病变是糖尿病最常见和最严重的微血管并发症之一。有许多因素导致糖尿病视网膜病变,其发病机制仍不清楚。目前,对于糖尿病视网膜病变的早期治疗还没有有效的措施,当糖尿病进展到晚期时,可供选择的治疗方法非常有限,治疗效果往往不尽人意。详细研究糖尿病视网膜病变发病机制的分子机制和新治疗药物的开发对于实验研究和临床实践都具有重要意义。本文综述了糖尿病视网膜病变的潜在发病机制,为实验研究和临床实践提供参考。