Liu Yameng, Zhang Yu, Zhang Hailong, Xu Dianqin, Zhou Xinzhu, Xie Luhong, Xi Hongli, Zhu Yurong, Yang Hanlin, Zhu Xiaoyu, Ren Ji, Min Shaoju, Tan Yujie
Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.
School of Clinical Medicine, Guizhou Medical University, Guiyang, 550004, China.
Sci Rep. 2025 Jul 1;15(1):20618. doi: 10.1038/s41598-025-07201-4.
Cervical cancer is the fourth most common malignant tumor in women, lacking specific and sensitive markers. TP53 induced glycolysis regulatory phosphatase (TIGAR) plays an important role in the initiation and progression of several solid tumors. This study aims to investigate the diagnostic and prognostic and immunotherapeutic role of TIGAR in cervical cancer. We observed that TIGAR expression was upregulated in cervical cancer cells and tissues using experiments and bioinformatics analyses. Moreover, elevated TIGAR expression was associated with poor prognosis using Kaplan-Meier survival analysis, and its diagnostic value was confirmed using the Receiver operating characteristic (ROC) curve. We also analyzed the correlation between TIGAR expression and immune infiltration and assessed its correlation with a clinical cohort of cervical cancer, and found that TIGAR expression was significantly associated with the infiltration levels of Foxp3 + Treg cells, CD11b + MDSC, CTLA4, and HAVCR2. TIGAR is a potential diagnostic and prognostic biomarker of cervical cancer and is expected to offer new possibilities for cervical cancer immunotherapy.
宫颈癌是女性中第四常见的恶性肿瘤，缺乏特异性和敏感的标志物。TP53诱导的糖酵解调节磷酸酶（TIGAR）在几种实体瘤的发生和发展中起重要作用。本研究旨在探讨TIGAR在宫颈癌中的诊断、预后及免疫治疗作用。我们通过实验和生物信息学分析观察到，TIGAR在宫颈癌细胞和组织中的表达上调。此外，使用Kaplan-Meier生存分析发现TIGAR表达升高与预后不良相关，并使用受试者工作特征（ROC）曲线证实了其诊断价值。我们还分析了TIGAR表达与免疫浸润之间的相关性，并评估了其与宫颈癌临床队列的相关性，发现TIGAR表达与Foxp3 + Treg细胞、CD11b + MDSC、CTLA4和HAVCR2的浸润水平显著相关。TIGAR是宫颈癌潜在的诊断和预后生物标志物，有望为宫颈癌免疫治疗提供新的可能性。
