• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

HELLS 在泛癌中的诊断、预后和免疫作用：生物信息学分析。

Diagnostic, Prognostic, and Immunological Roles of HELLS in Pan-Cancer: A Bioinformatics Analysis.

机构信息

Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.

Department of Anesthesiology, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong, China.

出版信息

Front Immunol. 2022 Jun 14;13:870726. doi: 10.3389/fimmu.2022.870726. eCollection 2022.

DOI:10.3389/fimmu.2022.870726
PMID:35774795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9237247/
Abstract

BACKGROUND

Inappropriate repair of DNA damage drives carcinogenesis. Lymphoid-specific helicase (HELLS) is an important component of the chromatin remodeling complex that helps repair DNA through various mechanisms such as DNA methylation, histone posttranslational modification, and nucleosome remodeling. Its role in human cancer initiation and progression has garnered recent attention. Our study aims to provide a more systematic and comprehensive understanding of the role of HELLS in the development and progression of multiple malignancies through analysis of HELLS in cancers.

METHODS

We explored the role of HELLS in cancers using The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) database. Multiple web platforms and software were used for data analysis, including R, Cytoscape, HPA, Archs4, TISIDB, cBioPortal, STRING, GSCALite, and CancerSEA.

RESULTS

High HELLS expression was found in a variety of cancers and differentially expressed across molecular and immune subtypes. HELLS was involved in many cancer pathways. Its expression positively correlated with Th2 and Tcm cells in most cancers. It also correlated with genetic markers of immunomodulators in various cancers.

CONCLUSIONS

Our study elucidates the role HELLS plays in promotion, inhibition, and treatment of different cancers. HELLS is a potential cancer diagnostic and prognostic biomarker with immune, targeted, or cytotoxic therapeutic value. This work is a prerequisite to clinical validation and treatment of HELLS in cancers.

摘要

背景

DNA 损伤的不当修复会导致癌症的发生。淋巴特异性解旋酶（HELLS）是染色质重塑复合物的重要组成部分，有助于通过多种机制修复 DNA，如 DNA 甲基化、组蛋白翻译后修饰和核小体重塑。它在人类癌症的起始和进展中的作用引起了最近的关注。我们的研究旨在通过分析癌症中的 HELLS，为理解 HELLS 在多种恶性肿瘤的发生和进展中的作用提供更系统和全面的认识。

方法

我们使用癌症基因组图谱（TCGA）和基因型-组织表达（GTEx）数据库来探索 HELLS 在癌症中的作用。使用 R、Cytoscape、HPA、Archs4、TISIDB、cBioPortal、STRING、GSCALite 和 CancerSEA 等多个网络平台和软件进行数据分析。

结果

在多种癌症中发现 HELLS 高表达，且在分子和免疫亚型上存在差异表达。HELLS 参与了许多癌症途径。它的表达与大多数癌症中的 Th2 和 Tcm 细胞呈正相关。它还与各种癌症中免疫调节剂的遗传标志物相关。

结论

我们的研究阐明了 HELLS 在不同癌症的促进、抑制和治疗中的作用。HELLS 是一种潜在的癌症诊断和预后生物标志物，具有免疫、靶向或细胞毒性治疗价值。这项工作是在癌症中对 HELLS 进行临床验证和治疗的前提。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/268e953eca9c/fimmu-13-870726-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/4e1777bc9380/fimmu-13-870726-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/a8c0e381e771/fimmu-13-870726-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/6a0ead8c9a26/fimmu-13-870726-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/607d33db1fc9/fimmu-13-870726-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/72a82bca94c5/fimmu-13-870726-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/3b91bcd54dbb/fimmu-13-870726-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/a9506680d143/fimmu-13-870726-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/83f1cab85182/fimmu-13-870726-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/809072e9ac6b/fimmu-13-870726-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/39fa1aba1a0e/fimmu-13-870726-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/7ae47d1f995c/fimmu-13-870726-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/268e953eca9c/fimmu-13-870726-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/4e1777bc9380/fimmu-13-870726-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/a8c0e381e771/fimmu-13-870726-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/6a0ead8c9a26/fimmu-13-870726-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/607d33db1fc9/fimmu-13-870726-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/72a82bca94c5/fimmu-13-870726-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/3b91bcd54dbb/fimmu-13-870726-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/a9506680d143/fimmu-13-870726-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/83f1cab85182/fimmu-13-870726-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/809072e9ac6b/fimmu-13-870726-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/39fa1aba1a0e/fimmu-13-870726-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/7ae47d1f995c/fimmu-13-870726-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96e/9237247/268e953eca9c/fimmu-13-870726-g012.jpg

相似文献

1
Diagnostic, Prognostic, and Immunological Roles of HELLS in Pan-Cancer: A Bioinformatics Analysis.HELLS 在泛癌中的诊断、预后和免疫作用：生物信息学分析。
Front Immunol. 2022 Jun 14;13:870726. doi: 10.3389/fimmu.2022.870726. eCollection 2022.
2
Comprehensive bioinformatics analysis of FXR1 across pan-cancer: Unraveling its diagnostic, prognostic, and immunological significance.跨癌症全面的 FXR1 生物信息学分析：揭示其诊断、预后和免疫学意义。
Medicine (Baltimore). 2023 Dec 1;102(48):e36456. doi: 10.1097/MD.0000000000036456.
3
Immunological function and prognostic value of lymphoid-specific helicase in liver hepatocellular carcinoma.肝脏肝细胞癌中淋巴特异性解旋酶的免疫功能及预后价值
Cancer Biomark. 2023;38(2):225-239. doi: 10.3233/CBM-230073.
4
HELLS Regulates Chromatin Remodeling and Epigenetic Silencing of Multiple Tumor Suppressor Genes in Human Hepatocellular Carcinoma.HELLS 调控人肝细胞癌中多个肿瘤抑制基因的染色质重塑和表观遗传沉默。
Hepatology. 2019 May;69(5):2013-2030. doi: 10.1002/hep.30414. Epub 2019 Mar 27.
5
The Chromatin Remodeler HELLS: A New Regulator in DNA Repair, Genome Maintenance, and Cancer.染色质重塑酶 HELLS：DNA 修复、基因组维护和癌症的新调控因子。
Int J Mol Sci. 2022 Aug 18;23(16):9313. doi: 10.3390/ijms23169313.
6
A pan-cancer analysis of the role of USP5 in human cancers.泛癌症分析 USP5 在人类癌症中的作用。
Sci Rep. 2023 Jun 2;13(1):8972. doi: 10.1038/s41598-023-35793-2.
7
Utility of G protein-coupled oestrogen receptor 1 as a biomarker for pan-cancer diagnosis, prognosis and immune infiltration: a comprehensive bioinformatics analysis.G 蛋白偶联雌激素受体 1 作为一种用于泛癌诊断、预后和免疫浸润的生物标志物的效用：一项综合的生物信息学分析。
Aging (Albany NY). 2023 Nov 2;15(21):12021-12067. doi: 10.18632/aging.205162.
8
Pan-cancer analysis reveals correlation between RAB3B expression and tumor heterogeneity, immune microenvironment, and prognosis in multiple cancers.泛癌分析揭示 RAB3B 表达与多种癌症肿瘤异质性、免疫微环境和预后的相关性。
Sci Rep. 2024 Apr 30;14(1):9881. doi: 10.1038/s41598-024-60581-x.
9
A pan-cancer analysis of prognostic significance and immunological role of lysosomal-associated membrane protein 3.泛癌症分析溶酶体相关膜蛋白 3 的预后意义和免疫作用。
J Cell Mol Med. 2024 Feb;28(3):e18088. doi: 10.1111/jcmm.18088. Epub 2023 Dec 26.
10
A Pan-Cancer Analysis of SMARCA4 Alterations in Human Cancers.泛癌症分析人类癌症中 SMARCA4 改变。
Front Immunol. 2021 Oct 4;12:762598. doi: 10.3389/fimmu.2021.762598. eCollection 2021.

引用本文的文献

1
Pan-cancer analysis of UDP-glucose 6-dehydrogenase in human tumors and its function in hepatocellular carcinoma.人类肿瘤中UDP-葡萄糖6-脱氢酶的泛癌分析及其在肝细胞癌中的功能
World J Gastrointest Oncol. 2025 Jul 15;17(7):105981. doi: 10.4251/wjgo.v17.i7.105981.
2
Multi-omics analysis of the effects of pla2g4a on the prognosis of various cancers and its experimental validation in breast cancer cell lines.磷脂酶A2γ4a（PLA2G4A）对各种癌症预后影响的多组学分析及其在乳腺癌细胞系中的实验验证
Discov Oncol. 2025 Jul 7;16(1):1278. doi: 10.1007/s12672-025-03118-6.
3
TIGAR regulated by HPV E6 is correlated with disease stage, drug sensitivity, and immune microenvironment in cervical cancer.

本文引用的文献

1
The Epithelial-Mesenchymal Transition at the Crossroads between Metabolism and Tumor Progression.上皮-间充质转化在代谢与肿瘤进展的交汇点。
Int J Mol Sci. 2022 Jan 12;23(2):800. doi: 10.3390/ijms23020800.
2
HELLS Is Negatively Regulated by Wild-Type P53 in Liver Cancer by a Mechanism Involving P21 and FOXM1.在肝癌中，野生型P53通过涉及P21和FOXM1的机制对HELLS进行负调控。
Cancers (Basel). 2022 Jan 17;14(2):459. doi: 10.3390/cancers14020459.
3
PLOD3 regulates the expression of YAP1 to affect the progression of non-small cell lung cancer via the PKCδ/CDK1/LIMD1 signaling pathway.
由人乳头瘤病毒E6调控的TIGAR与宫颈癌的疾病分期、药物敏感性及免疫微环境相关。
Sci Rep. 2025 Jul 1;15(1):20618. doi: 10.1038/s41598-025-07201-4.
4
Unveiling the hidden role of SDHA in breast cancer proliferation: a novel therapeutic avenue.揭示SDHA在乳腺癌增殖中的隐藏作用：一条新的治疗途径。
Cancer Cell Int. 2025 Mar 21;25(1):108. doi: 10.1186/s12935-025-03746-6.
5
Transcriptome profiling revealed multiple circadian rhythm-related genes associated with common gynecological cancers.转录组分析揭示了多个与常见妇科癌症相关的昼夜节律相关基因。
Front Oncol. 2025 Jan 29;15:1422122. doi: 10.3389/fonc.2025.1422122. eCollection 2025.
6
Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC.综合多组学分析表明，CDC6是包括肝癌在内的多种癌症类型的潜在预后和免疫治疗生物标志物。
Transl Oncol. 2025 Mar;53:102314. doi: 10.1016/j.tranon.2025.102314. Epub 2025 Feb 3.
7
Unveiling the role of ASPP1 in cancer progression: pan-cancer bioinformatics and experimental validation in colorectal cancer.揭示ASPP1在癌症进展中的作用：泛癌生物信息学及结直肠癌实验验证
Front Oncol. 2025 Jan 2;14:1529809. doi: 10.3389/fonc.2024.1529809. eCollection 2024.
8
Analysis of the role of in the development and progression of hepatocellular carcinoma.关于[具体内容]在肝细胞癌发生发展过程中作用的分析。 （注：原文中“of”后面缺少具体内容）
Transl Cancer Res. 2024 Sep 30;13(9):5003-5020. doi: 10.21037/tcr-23-2398. Epub 2024 Sep 27.
9
mRNA and serum APOA1 protein as diagnostic and prognostic biomarkers in gastric cancer.信使核糖核酸和血清载脂蛋白A1蛋白作为胃癌诊断和预后的生物标志物
Transl Cancer Res. 2024 May 31;13(5):2141-2154. doi: 10.21037/tcr-23-1966. Epub 2024 May 23.
PLD3 通过 PKCδ/CDK1/LIMD1 信号通路调节 YAP1 的表达，影响非小细胞肺癌的进展。
Lab Invest. 2022 Apr;102(4):440-451. doi: 10.1038/s41374-021-00674-7. Epub 2022 Jan 17.
4
Rigosertib and Cholangiocarcinoma: A Cell Cycle Affair.里戈塞替尼与胆管癌：细胞周期相关。
Int J Mol Sci. 2021 Dec 25;23(1):213. doi: 10.3390/ijms23010213.
5
Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy.DNA 损伤反应在免疫和癌症免疫治疗中的功能和分子机制。
Front Immunol. 2021 Dec 14;12:797880. doi: 10.3389/fimmu.2021.797880. eCollection 2021.
6
Sempervirine Mediates Autophagy and Apoptosis the Akt/mTOR Signaling Pathways in Glioma Cells.永生青藤碱介导胶质瘤细胞中的自噬和凋亡以及Akt/mTOR信号通路。
Front Pharmacol. 2021 Nov 30;12:770667. doi: 10.3389/fphar.2021.770667. eCollection 2021.
7
FGFR1 Overexpression Induces Cancer Cell Stemness and Enhanced Akt/Erk-ER Signaling to Promote Palbociclib Resistance in Luminal A Breast Cancer Cells.FGFR1 过表达诱导癌细胞干性和增强 Akt/Erk-ER 信号促进 Luminal A 型乳腺癌细胞对帕博西利的耐药性。
Cells. 2021 Nov 4;10(11):3008. doi: 10.3390/cells10113008.
8
Screening and predicted value of potential biomarkers for breast cancer using bioinformatics analysis.基于生物信息学分析的乳腺癌潜在生物标志物的筛选及预测价值
Sci Rep. 2021 Oct 21;11(1):20799. doi: 10.1038/s41598-021-00268-9.
9
Overexpression of DTL enhances cell motility and promotes tumor metastasis in cervical adenocarcinoma by inducing RAC1-JNK-FOXO1 axis.DTL 的过表达通过诱导 RAC1-JNK-FOXO1 轴增强宫颈腺癌中的细胞迁移并促进肿瘤转移。
Cell Death Dis. 2021 Oct 11;12(10):929. doi: 10.1038/s41419-021-04179-5.
10
Harnessing DNA Repair Defects to Augment Immune-Based Therapies in Triple-Negative Breast Cancer.利用DNA修复缺陷增强三阴性乳腺癌的免疫治疗
Front Oncol. 2021 Sep 24;11:703802. doi: 10.3389/fonc.2021.703802. eCollection 2021.