Zhang Yifan, Chen Wei, Zhu Jiageng, Xu Luwei
Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Cell Death Discov. 2025 Jul 1;11(1):296. doi: 10.1038/s41420-025-02569-8.
Migrasomes are recently identified extracellular vesicles that are specifically generated by migrating cells. These pomegranate-like, membrane-bound organelles are released at the trailing edge during cell migration and play crucial roles in cell-to-cell communication, intercellular signaling, and tissue remodeling. Migrasomes selectively package various molecular components, including proteins, lipids, and RNA, facilitating a unique form of cellular communication known as migracytosis. They are involved in numerous physiological and pathological processes, including immune responses, cancer metastasis, tissue repair, and embryonic development. In this review, we provide an in-depth analysis of the biogenesis, structural features, and molecular composition of migrasomes. We further explore the emerging roles of migrasomes in disease pathogenesis, particularly their potential in cancer, neurodegenerative diseases, and immune modulation. Overall, this review aims to offer comprehensive insights into the latest research on migrasomes, while addressing the challenges in their study and potential avenues for future clinical implementation.
迁移小体是最近发现的一种细胞外囊泡，由迁移细胞特异性产生。这些石榴状的、有膜包裹的细胞器在细胞迁移过程中于细胞后缘释放，在细胞间通讯、细胞间信号传导和组织重塑中发挥关键作用。迁移小体选择性地包裹各种分子成分，包括蛋白质、脂质和RNA，促进一种独特的细胞通讯形式，即迁移胞吐作用。它们参与众多生理和病理过程，包括免疫反应、癌症转移、组织修复和胚胎发育。在这篇综述中，我们对迁移小体的生物发生、结构特征和分子组成进行了深入分析。我们进一步探讨了迁移小体在疾病发病机制中的新作用，特别是它们在癌症、神经退行性疾病和免疫调节中的潜力。总体而言，本综述旨在全面深入了解迁移小体的最新研究，同时应对其研究中的挑战以及未来临床应用的潜在途径。
