Migrasomes: Emerging organelles for unveiling physiopathology and advancing clinical implications.

Migrasomes are newly identified cellular organelles with a pomegranate-like structure and specifically generated by migrating cells. The mechanisms underlying migrasome biogenesis and methods for their isolation are gradually being elucidated. These organelles are pivotal in cell-to-cell communication and the maintenance of mitochondrial homeostasis. Their involvement in a diverse array of physiological and pathological processes is increasingly recognized. Despite these advancements, research on migrasomes is still in its early stages. It is imperative to delve deeper into the intricate mechanisms and functions of migrasomes to fully understand their role in physiopathology. In this review, we summarize the current research progress on migrasomes, including their distribution, biogenesis, purification and identification techniques, biological functionalities, and roles in physiological and pathological processes. We particularly highlight their potentials in disease diagnosis and therapy and point out the challenges facing us, aiming to provide novel insights into the emerging organelles.