Vallée Alexandre, Labbé Antoine, Arutkin Maxence, Baudouin Christophe, Vallée Jean-Noël
Department of Epidemiology and Public Health, Foch hospital, Suresnes, 92150, France.
IHU FOReSIGHT, Paris, France.
Sci Rep. 2025 Jul 1;15(1):22092. doi: 10.1038/s41598-025-05639-0.
The vascular theory posits that glaucoma is associated to ocular blood flow alterations. However, there is uncertainty regarding the association of arterial stiffness index (ASI) and pulse pressure (PP) to intraocular pressure (IOP). This study investigates the relationship between ASI and PP, and IOP, using the UK Biobank population. Among 89,930 participants of the UK Biobank population, ASI and PP were assessed, and their correlations with IOP were estimated using multiple linear and logistic regressions adjusted for age, sex, BMI, diabetes, dyslipidemia, mean blood pressure, heart rate, tobacco smoking status, previous CV diseases and antihypertensive therapy. Youden indices were determined for ASI at a value of 9.41 m/s and for PP at 49.18 mmHg to determine IOP > 21mmHg. After adjustment for all covariates, ASI > 9.41 m/s was significantly correlated with IOP levels, B = 0.054 [0.031; 0.076] and with IOP > 21 mmHg, OR = 1.057 [1.004-1.113]. PP > 49.18 mmHg was significantly associated with IOP levels, B = 0.378 [0.345; 0.401] and with IOP > 21 mmHg, OR = 1.558 [1.474-1.648]. Similar results were observed when considering ASI and PP at continuous levels. When considering participants with IOP < 21 mmHg (N = 83,079), ASI > 9.41 m/s and PP > 49.18 mmHg were significantly associated with IOP levels, B = 0.015 [0.008; 0.021], B = 0.286 [0.266; 0.306], respectively. We demonstrated that increased ASI and PP levels are associated with increased IOP. These findings provide new insight into the vascular theory between IOP and ASI.
血管理论认为青光眼与眼部血流改变有关。然而，关于动脉僵硬度指数（ASI）和脉压（PP）与眼内压（IOP）之间的关联尚不确定。本研究利用英国生物银行人群调查了ASI、PP与IOP之间的关系。在英国生物银行人群的89930名参与者中，评估了ASI和PP，并使用多线性和逻辑回归估计了它们与IOP的相关性，回归模型对年龄、性别、体重指数、糖尿病、血脂异常、平均血压、心率、吸烟状况、既往心血管疾病和抗高血压治疗进行了校正。确定了ASI值为9.41m/s和PP值为49.18mmHg时的约登指数，以确定IOP>21mmHg。在对所有协变量进行校正后，ASI>9.41m/s与IOP水平显著相关，B = 0.054[0.031；0.076]，与IOP>21mmHg显著相关，OR = 1.057[1.004 - 1.113]。PP>49.18mmHg与IOP水平显著相关，B = 0.378[0.345；0.401]，与IOP>21mmHg显著相关，OR = 1.558[1.474 - 1.648]。在考虑连续水平的ASI和PP时也观察到了类似结果。当考虑IOP<21mmHg的参与者（N = 83079）时，ASI>9.41m/s和PP>49.18mmHg分别与IOP水平显著相关，B = 0.015[0.008；0.021]，B = 0.286[0.266；0.306]。我们证明，ASI和PP水平升高与IOP升高有关。这些发现为IOP与ASI之间的血管理论提供了新的见解。
