Gan Li, Huang Litao, Li Lijuan, Yang Xin, Meng Lijiao, Pang Zijian, Wei Quan
Department of Adult Speech and Swallowing Therapy, Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, No. 37, Guo Xue Alley, Chengdu, 610041, China.
Sci Rep. 2025 Jul 1;15(1):22193. doi: 10.1038/s41598-025-06258-5.
Oral reading for language in aphasia (ORLA) therapy coupled with telerehabilitation (TR) is a promising adjunct to treatment for aphasia. This single-center, randomized, single-blind, 6-month trial aimed to evaluate whether ORLA combined with TR demonstrates comparable efficacy to conventional ORLA offline rehabilitation for improving comprehensive language ability in subacute aphasia patients while assessing longitudinal treatment effects. Enrolled patients were randomized 1:1:1 into Group A (medium-high intensity ORLA TR), Group B (low-intensity ORLA TR), and Group C (medium-high intensity ORLA offline). All groups received a 6-month, 90-h intervention comprising three treatment phases. The primary outcome was a change in Aphasia Quotient (AQ) at baseline and 4 weeks, 3 months, and 6 months post-treatment. The secondary outcomes included quality of life and language subscale scores at the same time points. A total of 42 participants were analyzed, Group A demonstrated a non-significant mean difference of - 0.62 (95% CI - 5.00 to 6.23; P = 0.825) in AQ compared to Group C. A statistically significant difference in the Stroke Aphasia Quality of Life-39 Scale (SAQOL-39) scores between Group A and Group C (mean difference: - 8.19; 95% CI [- 12.39, - 3.99]; P < 0.001). Group A vs. Group C: No statistically significant differences were observed in any of the aforementioned language subskills between Group A and Group C (P > 0.05 for all comparisons). ORLA combined with TR demonstrated comparable efficacy to conventional ORLA offline rehabilitation, serving as a viable alternative for home-based speech rehabilitation in subacute aphasia patients. This TR approach improved both comprehensive language ability and quality of life, with sustained treatment effects over time.First registration date: August 18, 2023 (retrospective registration, Chinese Clinical Trial Registry number: ChiCTR2300074870).
失语症语言朗读（ORLA）疗法联合远程康复（TR）是一种很有前景的失语症治疗辅助方法。这项单中心、随机、单盲、为期6个月的试验旨在评估ORLA联合TR在改善亚急性失语症患者综合语言能力方面是否与传统的线下ORLA康复具有相当的疗效，同时评估纵向治疗效果。纳入的患者按1:1:1随机分为A组（中高强度ORLA-TR）、B组（低强度ORLA-TR）和C组（中高强度线下ORLA）。所有组均接受为期6个月、共90小时的干预，包括三个治疗阶段。主要结局是治疗前基线以及治疗后4周、3个月和6个月时失语症商数（AQ）的变化。次要结局包括相同时间点的生活质量和语言子量表得分。共分析了42名参与者，与C组相比，A组的AQ平均差异为-0.62（95%CI -5.00至6.23；P = 0.825），差异无统计学意义。A组和C组在卒中失语症生活质量-39量表（SAQOL-39）得分上存在统计学显著差异（平均差异：-8.19；95%CI [-12.39, -3.99]；P < 0.001）。A组与C组比较：A组和C组在上述任何语言子技能方面均未观察到统计学显著差异（所有比较P > 0.05）。ORLA联合TR与传统的线下ORLA康复具有相当的疗效，是亚急性失语症患者居家言语康复的可行替代方案。这种TR方法改善了综合语言能力和生活质量，且治疗效果随时间持续存在。首次注册日期：2023年8月18日（回顾性注册，中国临床试验注册中心编号：ChiCTR2300074870）
