旋律语调疗法治疗中风后非流畅性失语：一项关于行为和弥散张量成像结果的临床初步研究。
Melodic intonation therapy for non-fluent aphasia after stroke: A clinical pilot study on behavioral and DTI findings.
作者信息
Zhang Xiaoying, Talifu Zuliyaer, Li Jianjun, Li Xiaobing, Yu Feng
机构信息
School of Rehabilitation Medicine, Capital Medical University, Beijing 100068, China.
Department of Music Artificial Intelligence and Music Information Technology, Central Conservatory of Music, Beijing 100038, China.
出版信息
iScience. 2023 Aug 23;26(9):107453. doi: 10.1016/j.isci.2023.107453. eCollection 2023 Sep 15.
Music-based melodic intonation therapy (MIT) has shown promise as a treatment for non-fluent aphasia after stroke. This trial compared the efficacy of music-based MIT and speech therapy (ST) in aphasia, focusing on arcuate fasciculus connectivity in brain structural and language ability scores. A total of 62 patients were enrolled, of whom 40 completed the trial. The experimental group received MIT for 30 min/d, five days per week for four weeks, while the control group received ST with the same dose. The BDAE and fMRI-DTI were performed at T0 and T1. The music-based MIT group demonstrated better language levels. DTI showed that FA, FN, and path length of the MIT group in the right hemisphere were significantly increased. Music-based MIT had positive effects on reorganization and activation of arcuate fasciculus in aphasia after stroke. This research is funded by NSFC No. T2341003 and No.2020CZ-10. Clinical Trials ChiCTR2000037871. Ethics approval number: 2020-013-1.
基于音乐的旋律语调疗法（MIT）已显示出有望成为中风后非流利性失语症的一种治疗方法。本试验比较了基于音乐的MIT和言语疗法（ST）在失语症治疗中的疗效，重点关注脑结构中弓状束的连通性和语言能力评分。共招募了62名患者，其中40名完成了试验。实验组每天接受30分钟的MIT治疗，每周五天，共四周，而对照组接受相同剂量的ST治疗。在T0和T1时进行波士顿诊断性失语症检查（BDAE）和功能磁共振成像-弥散张量成像（fMRI-DTI）。基于音乐的MIT组表现出更好的语言水平。DTI显示，MIT组右半球的分数各向异性（FA）、纤维数量（FN）和路径长度显著增加。基于音乐的MIT对中风后失语症患者弓状束的重组和激活有积极作用。本研究由国家自然科学基金项目编号T2341003和2020CZ-10资助。临床试验注册号：ChiCTR2000037871。伦理批准号：2020-013-1。
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