Grzesik-Pietrasiewicz Michalina, Łach Kornelia, Brożyna Maciej, Przednowek Krzysztof, Podgórski Rafał
Department of Medicinal Chemistry and Metabolomics, Faculty of Medicine, University of Rzeszów, Tadeusza Rejtana 16C, 35-959, Rzeszów, Poland.
Faculty of Physical Culture Sciences, University of Rzeszów, Rzeszów, Poland, Tadeusza Rejtana 16C, 35-959.
Sci Rep. 2025 Jul 1;15(1):21853. doi: 10.1038/s41598-025-06270-9.
The SERE course provides a unique environment to study physiological stress responses under highly demanding training conditions, offering an exceptional opportunity for study. The purpose of this research was to determine the impact of SERE training on the secretion of selected neurotransmitters in special forces soldiers. We measured levels of epinephrine, serotonin, and oxytocin at two time points-during SERE training and after a one-month recovery period-and compared these results with a control group. Measurements were conducted using commercially available enzyme-linked immunosorbent assays. To our knowledge, this is the first study to describe changes in oxytocin and serotonin secretion in the context of SERE training. Our findings showed an increase in the concentrations of epinephrine, serotonin, and oxytocin in response to the stress of SERE training compared to the control group. The concentration of selected hormones, one month after completing the course, was lower than during the SERE training, but only the difference in epinephrine was statistically significant. Moreover, we found positive correlations between all the studied hormones. Our results suggest that elevated levels of these hormones during SERE training reflect the body's adaptive response to acute stress. Collectively, these biomarkers play a vital role in enabling soldiers to survive and perform effectively under extreme conditions.
生存、逃避、抵抗和逃脱(SERE)课程提供了一个独特的环境,用于研究在高要求训练条件下的生理应激反应,为研究提供了绝佳机会。本研究的目的是确定SERE训练对特种部队士兵中选定神经递质分泌的影响。我们在两个时间点测量了肾上腺素、血清素和催产素的水平,一个是在SERE训练期间,另一个是在为期一个月的恢复期后,并将这些结果与一个对照组进行了比较。测量是使用市售的酶联免疫吸附测定法进行的。据我们所知,这是第一项描述在SERE训练背景下催产素和血清素分泌变化的研究。我们的研究结果表明,与对照组相比,SERE训练的应激导致肾上腺素、血清素和催产素的浓度增加。课程结束一个月后,选定激素的浓度低于SERE训练期间,但只有肾上腺素的差异具有统计学意义。此外,我们发现所有研究的激素之间都存在正相关。我们的结果表明,SERE训练期间这些激素水平的升高反映了身体对急性应激的适应性反应。总体而言,这些生物标志物在使士兵在极端条件下生存并有效执行任务方面发挥着至关重要的作用。