血清素在神经精神疾病中的作用。
The Roles of Serotonin in Neuropsychiatric Disorders.
机构信息
Division of Neuroscience, Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Cell Mol Neurobiol. 2022 Aug;42(6):1671-1692. doi: 10.1007/s10571-021-01064-9. Epub 2021 Mar 2.
Abstract
The serotonergic system extends throughout the central nervous system (CNS) and the gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a broad spectrum of functions, including mood, cognition, anxiety, learning, memory, reward processing, and sleep. These processes are mediated through 5-HT binding to 5-HT receptors (5-HTRs), are classified into seven distinct groups. Deficits in the serotonergic system can result in various pathological conditions, particularly depression, schizophrenia, mood disorders, and autism. In this review, we outlined the complexity of serotonergic modulation of physiologic and pathologic processes. Moreover, we provided experimental and clinical evidence of 5-HT's involvement in neuropsychiatric disorders and discussed the molecular mechanisms that underlie these illnesses and contribute to the new therapies.
摘要
5-羟色胺能系统遍布中枢神经系统（CNS）和胃肠道（GI）。在中枢神经系统中，血清素（5-HT，5-羟色胺）调节着广泛的功能，包括情绪、认知、焦虑、学习、记忆、奖励处理和睡眠。这些过程是通过 5-HT 与 5-HT 受体（5-HTRs）结合介导的，分为七个不同的组。5-羟色胺能系统的缺陷会导致各种病理状况，特别是抑郁症、精神分裂症、情绪障碍和自闭症。在这篇综述中，我们概述了 5-羟色胺对生理和病理过程的调节的复杂性。此外，我们还提供了 5-HT 参与神经精神疾病的实验和临床证据，并讨论了这些疾病的潜在分子机制及其对新疗法的贡献。
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