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带负电荷膜上的阳离子氛围及阳离子竞争结合：铝的病理学意义

Cationic atmosphere and cation competition binding at negatively charged membranes: pathological implications of aluminum.

作者信息

Deleers M

出版信息

Res Commun Chem Pathol Pharmacol. 1985 Aug;49(2):277-94.

PMID:4059654
Abstract

Binding of cations to membranes may be the basis for explaining some of the effects of several neurotoxic cations. The binding of Al3+ and the displacement of Ca2+ by Al3+ is studied with the aid of a simple mathematical approach described here and giving the same results when compared to the mathematical formalism described by Nir and Bentz. The method allows the simulation of membranes with low surface charge densities that are relevant for biochemical and pathological implications. Fluorescence quenching of the phospholipid analogue 1-palmitoyl-2-nitrobenzoxadiazol amino caproyl- phosphatidyl choline (C6-NBD-Ptd Cho) embedded in phosphatidyl serine membranes is used to determine the competition between calcium and aluminum for binding. The effect of aluminum in the presence of chelating agents is also studied by quenching experiments. Finally, inhibition of 45Ca2+ binding to phosphatidyl serine has also been investigated in a two-phase system.

摘要

阳离子与膜的结合可能是解释几种神经毒性阳离子某些作用的基础。借助本文所述的一种简单数学方法研究了Al3+的结合以及Al3+对Ca2+的置换，与Nir和Bentz描述的数学形式主义相比，该方法给出了相同的结果。该方法允许模拟具有低表面电荷密度的膜，这与生化和病理学意义相关。嵌入磷脂酰丝氨酸膜中的磷脂类似物1-棕榈酰-2-硝基苯并恶二唑氨基己酰-磷脂酰胆碱（C6-NBD-Ptd Cho）的荧光猝灭用于确定钙和铝在结合上的竞争。还通过猝灭实验研究了螯合剂存在下铝的作用。最后，在两相系统中也研究了45Ca2+与磷脂酰丝氨酸结合的抑制作用。

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Cationic atmosphere and cation competition binding at negatively charged membranes: pathological implications of aluminum.带负电荷膜上的阳离子氛围及阳离子竞争结合：铝的病理学意义
Res Commun Chem Pathol Pharmacol. 1985 Aug;49(2):277-94.
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引用本文的文献

1
Aluminum effects on the kinetics of calcium uptake into cells of the wheat root apex : Quantification of calcium fluxes using a calcium-selective vibrating microelectrode.铝对小麦根尖细胞钙摄取动力学的影响：利用钙选择性振动微电极定量测定钙通量。
Planta. 1992 Oct;188(3):414-21. doi: 10.1007/BF00192809.
2
Electrostatic Changes in Lycopersicon esculentum Root Plasma Membrane Resulting from Salt Stress.盐胁迫导致番茄根质膜的静电变化
Plant Physiol. 1990 Jun;93(2):471-8. doi: 10.1104/pp.93.2.471.
3
Analysis of aluminum and divalent cation binding to wheat root plasma membrane proteins using terbium phosphorescence.
利用铽磷光分析法分析铝和二价阳离子与小麦根质膜蛋白的结合情况。
Plant Physiol. 1989 Sep;91(1):233-41. doi: 10.1104/pp.91.1.233.
4
Proton extrusion by wheat roots exhibiting severe aluminum toxicity symptoms.小麦根在严重铝毒害症状下的质子外排。
Plant Physiol. 1988 Oct;88(2):418-23. doi: 10.1104/pp.88.2.418.
5
Cation amelioration of aluminum toxicity in wheat.阳离子对小麦铝毒性的改善作用
Plant Physiol. 1987 Mar;83(3):546-51. doi: 10.1104/pp.83.3.546.
6
Aluminum-induced alteration of surface anionic sites in cultured brain microvascular endothelial cells.铝诱导培养的脑微血管内皮细胞表面阴离子位点的改变。
Acta Neuropathol. 1993;86(4):371-7. doi: 10.1007/BF00369450.
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Effect of aluminum and lead salts on lipid peroxidation and cell survival in human skin fibroblasts.铝盐和铅盐对人皮肤成纤维细胞脂质过氧化及细胞存活的影响。
Biol Trace Elem Res. 1995 Jan-Mar;47(1-3):57-67. doi: 10.1007/BF02790101.
8
Would decreased aluminum ingestion reduce the incidence of Alzheimer's disease?减少铝摄入量会降低阿尔茨海默病的发病率吗？
CMAJ. 1991 Oct 1;145(7):793-804.
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Aluminium modifies the electrical response of neuroblastoma cells to a short hypertonic pulse.铝改变神经母细胞瘤细胞对短暂高渗脉冲的电反应。
Arch Toxicol. 1992;66(2):90-4. doi: 10.1007/BF02342500.