McLachlan D R, Kruck T P, Lukiw W J, Krishnan S S
Department of Medicine, University of Toronto, Ont.
CMAJ. 1991 Oct 1;145(7):793-804.
Although the cause of Alzheimer's disease (AD) remains unknown there is mounting evidence that implicates aluminum as a toxic environmental factor of considerable importance. Four independent lines of evidence--laboratory studies of the effects of intracerebral aluminum on the cognitive and memory performance of animals, biochemical studies, epidemiologic studies and the slowing of the progress of the disease with the use of an agent that removes aluminum from the body--now support the concept that aluminum is one of the pathogenic factors in AD. The evidence warrants serious consideration of reducing human exposure to aluminum. We hypothesize that a public health effort to restrict human ingestion of aluminum would reduce the incidence of this common chronic illness in the elderly.
尽管阿尔茨海默病（AD）的病因仍不明确，但越来越多的证据表明铝是一个相当重要的有毒环境因素。四条独立的证据线索——关于脑内铝对动物认知和记忆表现影响的实验室研究、生化研究、流行病学研究以及使用一种能从体内去除铝的药物使疾病进展减缓——现在支持了铝是AD致病因素之一的观点。这些证据值得认真考虑减少人类对铝的接触。我们推测，一项限制人类摄入铝的公共卫生举措将降低老年人中这种常见慢性病的发病率。
