Shang Huihui, Wang Jiawei, Zhang Xinya, Zhang Dingli, Yue Kai, Xu Song
Department of Health Medicine, The 991 st Hospital of Joint Logistic Support Force of People's Liberation Army, Xiangyang, 441000, Hubei, China.
Department of Medical Service Office, The 991 st Hospital of Joint Logistic Support Force of People's Liberation Army, Xiangyang, 441000, Hubei, China.
BMC Infect Dis. 2025 Jul 1;25(1):814. doi: 10.1186/s12879-025-11202-z.
BACKGROUND/OBJECTIVES: Currently, the increased prevalence of Helicobacter pylori (H. pylori) infection and elevated levels of dyslipidemia pose a major public health challenge. We aimed to investigate the association between dyslipidemia and H. pylori infection from the perspective of age category. METHODS: A retrospective cross-sectional study was conducted on 3530 non-obese and non-diabetic individuals who underwent a physical examination at the 991st Hospital of the Joint Logistics Support Force of People's Liberation Army from January to December 2024. Physical measurements, hematological markers, and detection of H. pylori were gathered from all patients. According to the results of the detection of H. pylori, the subjects were divided into the H. pylori-positive group and the H. pylori-negative group. The correlation between H. pylori infection and blood lipid levels was compared between the two groups according to age category. Binary Logistic regression analysis was used to analyze the factors influencing H. pylori infection. RESULTS: Among 3530 healthy subjects, 1176 cases (33.31%) were in the H. pylori-positive group and 2354 cases (66.69%) were in the H. pylori-negative group. In the 30-59 age group, low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), and total cholesterol (TC) levels were significantly higher in H. pylori-positive individuals compared to H. pylori-negative individuals (P < 0.05), with no significant differences in other age groups (P > 0.05). Binary Logistic regression showed that H. pylori infection was associated with elevated LDL-c [OR = 2.100, 95%CI (1.771-2.491), P < 0.001], elevated TC [OR = 2.844, 95%CI (2.232-3.623), P < 0.001], male gender [OR = 1.267, 95%CI (1.054-1.524), P < 0.05], ages 40-49 [OR = 1.602, 95%CI (1.181-2.173), P < 0.05]. CONCLUSIONS: H. pylori infection is associated with dyslipidemia in non-obese and non-diabetic people, especially those aged 30-59. In men aged 40-49, H. pylori positivity was more strongly related to elevated TC and LDL-c, highlighting the importance of routine H. pylori screening in this age group.
背景/目的：目前，幽门螺杆菌（H. pylori）感染患病率的上升和血脂异常水平的升高构成了一项重大的公共卫生挑战。我们旨在从年龄组的角度研究血脂异常与幽门螺杆菌感染之间的关联。 方法：对2024年1月至12月在解放军联勤保障部队第991医院接受体检的3530名非肥胖、非糖尿病个体进行了一项回顾性横断面研究。收集了所有患者的体格测量、血液学指标以及幽门螺杆菌检测结果。根据幽门螺杆菌检测结果，将受试者分为幽门螺杆菌阳性组和幽门螺杆菌阴性组。根据年龄组比较两组之间幽门螺杆菌感染与血脂水平的相关性。采用二元Logistic回归分析来分析影响幽门螺杆菌感染的因素。 结果：在3530名健康受试者中，1176例（33.31%）属于幽门螺杆菌阳性组，2354例（66.69%）属于幽门螺杆菌阴性组。在30 - 59岁年龄组中，幽门螺杆菌阳性个体的低密度脂蛋白胆固醇（LDL - c）、甘油三酯（TG）和总胆固醇（TC）水平显著高于幽门螺杆菌阴性个体（P < 0.05），其他年龄组无显著差异（P > 0.05）。二元Logistic回归显示，幽门螺杆菌感染与LDL - c升高[比值比（OR）= 2.100，95%置信区间（CI）（1.771 - 2.491），P < 0.001]、TC升高[OR = 2.844，95%CI（2.232 - 3.623），P < 0.001]、男性性别[OR = 1.267，95%CI（1.054 - 1.524），P < 0.05]、40 - 49岁年龄[OR = 1.602，95%CI（1.181 - 2.173），P < 0.05]相关。 结论：幽门螺杆菌感染与非肥胖、非糖尿病人群的血脂异常有关，尤其是30 - 59岁的人群。在40 - 49岁男性中，幽门螺杆菌阳性与TC和LDL - c升高的相关性更强，突出了该年龄组常规幽门螺杆菌筛查的重要性。
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