Huang Jiaqi, Jiang Qiaozhi, Liu Jiaxuan, Mei Guocheng, Tao Renchuan
Department of Periodontics and Oral Medicine, College of Stomatology, Guangxi Medical University, Nanning, Guangxi, China.
Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Universities and Colleges Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Clinical Research Center for Craniofacial Deformity, Nanning, Guangxi, China.
BMC Oral Health. 2025 Jul 1;25(1):968. doi: 10.1186/s12903-025-06333-3.
Patients who undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT) frequently experience immunodeficiency, predisposing them to graft-versus-host disease (GVHD) and viral infection. The oral cavity is a common organ affected by chronic GVHD(cGVHD), which can lead to the development of secondary malignant tumors such as oral squamous cell carcinoma (OSCC). Verrucous carcinoma is a low-grade variant of SCC with specific morphologic, cytokinetic and clinical features. It is a locally aggressive tumour and does not metastasize to regional lymph nodes or to distant sites. This case report describes a patient with cGVHD following allo-HSCT who developed extensive oral verrucous carcinoma in the oral mucosa. This observation underscores the importance of regular oral examinations for transplant recipients, particularly those with cGVHD, to monitor HPV infection and the potential development of verrucous carcinoma.
接受异基因造血干细胞移植（allo-HSCT）的患者经常会出现免疫缺陷，使他们易患移植物抗宿主病（GVHD）和病毒感染。口腔是慢性移植物抗宿主病（cGVHD）常累及的器官，可导致继发性恶性肿瘤的发生，如口腔鳞状细胞癌（OSCC）。疣状癌是鳞状细胞癌的一种低级别变体，具有特定的形态学、细胞动力学和临床特征。它是一种局部侵袭性肿瘤，不会转移至区域淋巴结或远处部位。本病例报告描述了一名allo-HSCT后发生cGVHD的患者，其口腔黏膜出现广泛的口腔疣状癌。这一观察结果强调了对移植受者，尤其是患有cGVHD的受者进行定期口腔检查以监测HPV感染及疣状癌潜在发生的重要性。
