Alonso Jose E, Kuan Edward C, Arshi Armin, St John Maie A
Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA; the UCLA Head and Neck Cancer Program, Los Angeles, California, U.S.A.
Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA; the UCLA Head and Neck Cancer Program, Los Angeles, California, U.S.A.
Laryngoscope. 2018 Feb;128(2):393-397. doi: 10.1002/lary.26745. Epub 2017 Aug 29.
To describe the incidence and determinants of survival of patients with verrucous carcinoma (VC) of the oral cavity between the years of 1973 and 2012 using the Surveillance, Epidemiology, and End Results (SEER) database.
Retrospective cohort study using a national database.
The SEER registry was utilized to calculate survival trends for patients with VC of the oral cavity between 1973 and 2012. Patient data was then analyzed with respect to histopathology, age, sex, race, stage, grade, and treatment modalities (surgery and radiation therapy). Overall survival (OS) and disease-specific survival (DSS) were calculated.
A total of 1,481 cases of VC of the oral cavity were identified. The cohort was composed of 50.5% males. The mean age at diagnosis was 69.5 years. The oral tongue was the most common primary site (28.9%), followed by the alveolar ridge (21.4%) and buccal mucosa (19.0%). The vast majority of cases (79.1%) presented with stage I and stage II disease. Nodal disease was present in only 1.6% of cases. The median OS was 94.6 months. Eighty-seven percent of cases underwent surgery, and 11.5% received both surgery and radiation therapy. Overall survival at 2, 5, and 10 years was 83%, 64%, and 42%, respectively. On multivariate analysis, advanced age (P < 0.001) and stage (P < 0.001) were associated with worse OS, whereas surgery improved OS (P = 0.047).
We provide the first population-based analysis of prognostic factors affecting survival outcomes in patients with oral cavity VC. Verrucous carcinoma of the oral cavity is associated with a generally favorable prognosis. Age, stage, nodal status, and surgical therapy are independent predictors of OS.
利用监测、流行病学和最终结果（SEER）数据库描述1973年至2012年间口腔疣状癌（VC）患者的发病率及生存决定因素。
使用国家数据库进行回顾性队列研究。
利用SEER登记处计算1973年至2012年间口腔VC患者的生存趋势。然后针对组织病理学、年龄、性别、种族、分期、分级和治疗方式（手术和放射治疗）对患者数据进行分析。计算总生存期（OS）和疾病特异性生存期（DSS）。
共识别出1481例口腔VC病例。该队列中男性占50.5%。诊断时的平均年龄为69.5岁。口腔舌部是最常见的原发部位（28.9%），其次是牙槽嵴（21.4%）和颊黏膜（19.0%）。绝大多数病例（79.1%）表现为I期和II期疾病。仅1.6%的病例出现淋巴结疾病。中位OS为94.6个月。87%的病例接受了手术，11.5%的病例接受了手术和放射治疗。2年、5年和10年的总生存率分别为83%、64%和42%。多因素分析显示，高龄（P＜0.001）和分期（P＜0.001）与较差的OS相关，而手术可改善OS（P = 0.047）。
我们首次对影响口腔VC患者生存结局的预后因素进行了基于人群的分析。口腔疣状癌通常预后良好。年龄、分期、淋巴结状态和手术治疗是OS的独立预测因素。
4。《喉镜》，128:393 - 397，2018年。
