丙泊酚辅助下小儿牙科治疗中的深度拔管:一项随机对照三盲试验
Propofol-assisted deep extubation in the dental treatment of pediatrics: a randomized controlled triple-blind trial.
作者信息
Cui Wei, Zhang Xiang, Shang Ying, Liu Yun
机构信息
Department of Stomatology, The No.2 Hospital of Baoding, Baoding, 071051, China.
Department of Anesthesiology, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
出版信息
BMC Anesthesiol. 2025 Jul 1;25(1):300. doi: 10.1186/s12871-025-03170-3.
OBJECTIVES
To verify whether propofol-assisted deep extubation is associated with fewer complications in pediatric patients undergoing dental treatment.
MATERIALS AND METHODS
This prospective study enrolled 60 pediatric candidates undergoing elective dental interventions, with randomized allocation to either deep extubation (DE; n = 30) or awake extubation (AE; n = 30) protocols. The primary endpoint was the incidence of at least 1 respiratory adverse event, whereas time to extubation (TOE), time to wake-up (TOW), hemodynamic fluctuations during extubation, incidence of emergence agitation (EA), nasal obstruction, epistaxis, sore throat, and hoarse voice after extubation were the secondary endpoints.
RESULTS
The DE group reported significantly lower incidence of at least 1 respiratory adverse event (0.0% VS 23.3%, P = 0.016). The TOE was significantly shorter in the DE group, averaging 2.78 ± 0.87 min, compared to 5.50 ± 1.01 min in the AE group (P < .001). The TOW was longer in the DE group, with an average of 15.03 ± 3.44 min compared to 10.63 ± 1.52 min in the AE group (P < .001). The average value of mean arterial pressure (AVMAP) during extubation was lower in the DE group at 74.70 ± 13.35 mmHg, compared to 87.43 ± 15.31 mmHg in the AE group (P < .001). The average value of heart rate (AVHR) in the DE group was 108.37 ± 13.41 bpm, while in the AE group, it was 127.93 ± 20.74 bpm (P < .001). Additionally, the rates of sore throat and hoarse voice were significantly lower in the DE group (6.7% and 3.3%) than in the AE group (27% and 30%).
CONCLUSIONS
For pediatric patients undergoing dental treatment, propofol-assisted deep extubation is superior, allowing for less extubation time without increasing airway complications. This technique provides a smoother extubation with fewer hemodynamic fluctuations and lower incidences of voice hoarseness and persistent coughing, provided that certain rules for deep extubation are followed.
目的
验证丙泊酚辅助深麻醉下拔管是否与接受牙科治疗的儿科患者较少的并发症相关。
材料与方法
这项前瞻性研究纳入了60名接受择期牙科干预的儿科患者,随机分配至深麻醉下拔管组(DE组;n = 30)或清醒拔管组(AE组;n = 30)。主要终点是至少发生1次呼吸不良事件的发生率,而拔管时间(TOE)、苏醒时间(TOW)、拔管期间的血流动力学波动、苏醒期躁动(EA)的发生率、鼻阻塞、鼻出血、咽痛和拔管后声音嘶哑为次要终点。
结果
DE组报告的至少发生1次呼吸不良事件的发生率显著更低(0.0%对23.3%,P = 0.016)。DE组的TOE显著更短,平均为2.78±0.87分钟,而AE组为5.50±1.01分钟(P < 0.001)。DE组的TOW更长,平均为15.03±3.44分钟,而AE组为10.63±1.52分钟(P < 0.001)。DE组拔管期间的平均动脉压(AVMAP)平均值更低,为74.70±13.35 mmHg,而AE组为87.43±15.31 mmHg(P < 0.001)。DE组的心率(AVHR)平均值为108.37±13.41次/分钟,而AE组为127.93±20.74次/分钟(P < 0.001)。此外,DE组的咽痛和声音嘶哑发生率(分别为6.7%和3.3%)显著低于AE组(分别为27%和30%)。
结论
对于接受牙科治疗的儿科患者,丙泊酚辅助深麻醉下拔管更具优势,可缩短拔管时间且不增加气道并发症。只要遵循深麻醉下拔管的某些规则,该技术可实现更平稳的拔管,血流动力学波动更少,声音嘶哑和持续性咳嗽的发生率更低。
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