自闭症谱系障碍与儿童龋齿：一项全面的孟德尔随机化研究。

Autism spectrum disorders and childhood caries: a comprehensive Mendelian randomization study.

作者信息

Jin Qiufang, He Zexiu, Xu Dongfang, Lin Ruihua, Zhang Tongtong, Lv Bingjian, Zhao Yuliang

机构信息

Department of Anesthesiology, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, 050000, Hebei, China.

Department of Pediatric Stomatology, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, 050000, Hebei, China.

出版信息

BMC Pediatr. 2025 Jul 2;25(1):484. doi: 10.1186/s12887-025-05839-7.

DOI:10.1186/s12887-025-05839-7

PMID:40597832

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12220140/

Abstract

BACKGROUND

This study aimed to investigate the causal relationships between autism spectrum disorder (ASD) or pervasive developmental disorder (PDD) (excluding ASD and Asperger's syndrome [AS]) and childhood caries (primary teeth and permanent teeth).

METHODS

We conducted two-sample Mendelian randomization (MR) analysis by utilizing summary-level data of ASD and PDD (excluding ASD and AS) as exposures, and childhood caries (primary teeth and permanent teeth) as outcomes.

RESULTS

The results showed that PDD (excluding ASD and AS) to be causally associated with caries in permanent teeth according to the inverse-variance weighted (IVW) (odds ratio [OR]: 1.151, 95%CI: 1.043-1.270, P = 0.005) and weighted median (OR: 1.159, 95%CI: 1.029-1.306, P = 0.015). However, according to the IVW (OR: 0.923, 95%CI: 0.873-1.003, P = 0.051), ASD might be causally associated with caries in permanent teeth. The results also showed no causal association between ASD or PDD (excluding ASD and AS) and caries in primary teeth.

CONCLUSIONS

Our study showed PDD (excluding ASD and AS) to have pathogenic effects on childhood caries of permanent teeth among a population of European ancestry. However, ASD was shown to have protective effects on childhood caries of permanent teeth.

摘要

背景

本研究旨在调查自闭症谱系障碍（ASD）或广泛性发育障碍（PDD）（不包括ASD和阿斯伯格综合征[AS]）与儿童龋齿（乳牙和恒牙）之间的因果关系。

方法

我们进行了两样本孟德尔随机化（MR）分析，将ASD和PDD（不包括ASD和AS）的汇总数据作为暴露因素，将儿童龋齿（乳牙和恒牙）作为结局。

结果

结果显示，根据逆方差加权（IVW）法（优势比[OR]：1.151，95%置信区间：1.043 - 1.270，P = 0.005）和加权中位数法（OR：1.159，95%置信区间：1.029 - 1.306，P = 0.015），PDD（不包括ASD和AS）与恒牙龋齿存在因果关联。然而，根据IVW法（OR：0.923，95%置信区间：0.873 - 1.003，P = 0.051），ASD可能与恒牙龋齿存在因果关联。结果还显示，ASD或PDD（不包括ASD和AS）与乳牙龋齿之间无因果关联。