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开角型青光眼患者白内障超声乳化联合小梁切开术后角膜生物力学和生物测量特性的变化

Changes of corneal biomechanical and biometrical properties after combined phacoemulsification with viscocanalostomy surgery in patients with open-angle glaucoma.

作者信息

Azimi Ali, Sadeghi Elham, Hassanipour Hamidreza, Bostanian Pardis, Attar Alireza, Eghtedari Dorna, Sharafi Zahra, Razmi Hooman, S Kumar Rajesh, Conner Ian

机构信息

Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

出版信息

BMC Ophthalmol. 2025 Jul 1;25(1):385. doi: 10.1186/s12886-025-04095-8.

Abstract

PURPOSE

To assess corneal biomechanical changes after phacoemulsification and ab-externo viscocanalostomy (phaco-visco) surgery in patients with open-angle glaucoma (OAG).

METHODS

Patients with OAG and cataract, visual acuity < 20/40 Snellen, were included. Pre- and postoperative evaluations were performed. Keratometric and aberrometry assessments were done with Oculus Pentacam AXL, and corneal biomechanics were evaluated using Corvis ST. Wilcoxon signed-rank and Chi-square tests were used.

RESULTS

This study included 30 eyes from 28 patients with OAG who underwent phaco-visco surgery. The mean age was 67.57 ± 9.20 years, with 50% being male. The mean postoperative follow-up duration was 4.1 ± 2.1 months. Postoperatively, biomechanically corrected intraocular pressure (bIOP) significantly decreased (-1.8 ± 4.7, P = 0.008), while central corneal thickness (CCT) showed no significant change (+ 0.333 ± 9.536, P = 0.810). Significant increases were observed in deflection amplitude max (+ 0.841 ± 0.173, P = 0.002), peak distance (+ 0.242 ± 0.458, P = 0.001), front astigmatism (+ 0.210 ± 0.420, P = 0.013), index of height asymmetry (+ 3.146 ± 6.374, P = 0.015), and index of height deviation (+ 0.007 ± 0.010, P = 0.001). Additionally, anterior chamber (AC) parameters such as AC depth (P = 0.001) and AC volume (P < 0.001) significantly increased following surgery.

CONCLUSIONS

This study shows that phaco-visco surgery in OAG eyes may increase corneal softening, decrease bIOP without altering CCT, induce corneal front astigmatism, and cause AC parameters changes. Corvis ST helps for more accurate IOP assessment and toric IOL planning.

摘要

目的

评估开角型青光眼(OAG)患者行白内障超声乳化吸除联合外路小梁切开术(phaco-visco)后的角膜生物力学变化。

方法

纳入患有OAG和白内障、视力<20/40 Snellen的患者。进行术前和术后评估。使用Oculus Pentacam AXL进行角膜曲率和像差测量评估,并使用Corvis ST评估角膜生物力学。采用Wilcoxon符号秩检验和卡方检验。

结果

本研究纳入了28例接受phaco-visco手术的OAG患者的30只眼。平均年龄为67.57±9.20岁,50%为男性。术后平均随访时间为4.1±2.1个月。术后,生物力学校正眼压(bIOP)显著降低(-1.8±4.7,P = 0.008),而中央角膜厚度(CCT)无显著变化(+0.333±9.536,P = 0.810)。观察到最大偏转幅度(+0.841±0.173,P = 0.002)、峰值距离(+0.242±0.458,P = 0.001)、前散光(+0.210±0.420,P = 0.013)、高度不对称指数(+3.146±6.374,P = 好015)和高度偏差指数(+0.007±0.010,P = 0.001)显著增加。此外,术后前房(AC)参数如前房深度(P = 0.001)和前房容积(P < 0.001)显著增加。

结论

本研究表明,OAG患者行phaco-visco手术可能会增加角膜软化,降低bIOP而不改变CCT,诱发角膜前散光,并导致AC参数改变。Corvis ST有助于更准确地评估眼压和规划散光人工晶状体。

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本文引用的文献

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Surgically Induced Astigmatism after Cataract Surgery - A Vector Analysis.白内障手术后的手术源性散光——向量分析。
Curr Eye Res. 2022 Sep;47(9):1279-1287. doi: 10.1080/02713683.2022.2052108. Epub 2022 Jul 25.
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The surgical management of glaucoma: A review.青光眼的手术治疗:综述。
Clin Exp Ophthalmol. 2022 Mar;50(2):213-231. doi: 10.1111/ceo.14028. Epub 2022 Jan 17.
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Lancet Glob Health. 2021 Apr;9(4):e489-e551. doi: 10.1016/S2214-109X(20)30488-5. Epub 2021 Feb 16.
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Glaucoma surgery and induced astigmatism: a systematic review.青光眼手术与诱导性散光:一项系统综述。
Eye Vis (Lond). 2017 Nov 17;4:27. doi: 10.1186/s40662-017-0090-x. eCollection 2017.

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