Pontiroli A E, Alberetto M, Pozza G
Ric Clin Lab. 1985 Apr-Jun;15(2):185-8. doi: 10.1007/BF03029838.
In three hyperthyroid women aged more than 60 years serum TSH levels, inhibited as usual before treatment, rose and remained elevated for more than one year while on treatment with methimazole and l-thyroxine, in spite of serum T3 and T4 levels within the normal range. In two hypothyroid women aged more than 60 years, serum TSH levels, raised under basal conditions, failed to be suppressed by a one-year treatment with l-thyroxine. Repeated attempts to increase serum T3 and T4 concentrations by giving additional doses of l-thyroxine or by tapering methimazole dosage, led to clinical signs of hyperthyroidism, not accompanied by a significant reduction of serum TSH levels. These data indicate the possibility of an inappropriate TSH release in some elderly people.
在3名年龄超过60岁的甲状腺功能亢进女性中，血清促甲状腺激素（TSH）水平在治疗前如往常一样受到抑制，但在接受甲巯咪唑和左甲状腺素治疗期间却升高且持续超过一年，尽管血清三碘甲状腺原氨酸（T3）和甲状腺素（T4）水平在正常范围内。在2名年龄超过60岁的甲状腺功能减退女性中，基础状态下升高的血清TSH水平在接受一年的左甲状腺素治疗后未能被抑制。通过额外增加左甲状腺素剂量或逐渐减少甲巯咪唑剂量来反复尝试提高血清T3和T4浓度，导致出现甲状腺功能亢进的临床症状，但血清TSH水平并未显著降低。这些数据表明，一些老年人可能存在促甲状腺激素释放异常的情况。
