Kvetny J, Wandrup J
Scand J Clin Lab Invest. 1986 Sep;46(5):489-93. doi: 10.3109/00365518609083702.
Nuclear binding of [125I]T4 in human mononuclear blood cells was examined in six hyperthyroid and six hypothyroid patients before and after treatment. In hypothyroid patients the nuclear T4 binding was initially increased and subsequently normalized as the patients became euthyroid suggesting a homeostatic counter-regulation. The thyroid state did not affect the nuclear T4 binding in hyperthyroid patients. Treatment with methimazol however increased the nuclear T4 binding, suggesting either a direct effect of methimazol on the hormone-receptor interaction or that the patients had become slightly hypothyroid during the treatment. The TSH was shown not to affect nuclear T4 binding. The thyroid state of the patients did not significantly affect the nuclear accumulation of the T3 produced intracellularly by deiodination of T4.
对6例甲状腺功能亢进患者和6例甲状腺功能减退患者治疗前后的人单核血细胞中[125I]T4的核结合情况进行了检测。在甲状腺功能减退患者中，核T4结合最初增加，随后随着患者甲状腺功能恢复正常而恢复正常，提示存在稳态的反调节。甲状腺状态对甲状腺功能亢进患者的核T4结合没有影响。然而，甲巯咪唑治疗增加了核T4结合，这表明要么甲巯咪唑对激素-受体相互作用有直接影响，要么患者在治疗期间已变得轻度甲状腺功能减退。结果显示促甲状腺激素不影响核T4结合。患者的甲状腺状态对T4脱碘产生的细胞内T3的核蓄积没有显著影响。
