Zhou Hang, Zhang Yu-Xuan, Lei Quan-Kai, Li Yu-Mei, Zheng Yun-Wen
Institute of Regenerative Medicine, Department of Dermatology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, Jiangsu, China.
Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, Guangdong, China.
Stem Cell Res Ther. 2025 Jul 1;16(1):338. doi: 10.1186/s13287-025-04447-7.
Hair loss is a prevalent condition that affects many people worldwide and is often associated with self-neglect and anxiety. Hair transplantation is emerging as a viable therapeutic option for addressing several forms of hair loss that are resistant to pharmacological treatments. The etiology of hair loss is multifactorial and includes genetic predisposition, psychological factors, exposure to toxic agents, nutritional deficiencies, and mechanical stress. However, existing treatments, including topical medications, oral therapies, and phototherapy, often fail to provide comprehensive solutions. As a result, hair transplantation is currently the primary option for patients seeking a permanent solution to their hair loss. In this study, we systematically evaluated different hair follicle transplantation techniques and analyzed their respective advantages and limitations. Our results show that challenges such as limited hair follicle supply, suboptimal follicle survival rates, and recurrent hair loss hinder the effectiveness of transplantation, leaving many patients unsatisfied with the available options. Fortunately, advances in regenerative medicine, particularly the development of single-cell-integrated hair follicles or skin organoids derived from induced pluripotent stem cells, offer promising alternatives. These innovations have the potential to provide a substantial supply of uniform hair follicles tailored to the specific needs of individual patients, thereby expanding treatment options for those inadequately served by conventional methods. In summary, apart from a limited range of topical and systemic treatments, hair transplantation is often a last resort for people with hair loss. The potential to generate new hair follicles or organoids heralds a new era for large-scale clinical applications and the establishment of standardized treatment protocols.
脱发是一种普遍存在的病症，影响着全球许多人，并且常常与自我忽视和焦虑相关。植发正成为一种可行的治疗选择，用于解决几种对药物治疗有抗性的脱发形式。脱发的病因是多因素的，包括遗传易感性、心理因素、接触有毒物质、营养缺乏和机械压力。然而，现有的治疗方法，包括局部用药、口服疗法和光疗，往往无法提供全面的解决方案。因此，植发目前是寻求永久性脱发解决方案的患者的主要选择。在本研究中，我们系统地评估了不同的毛囊移植技术，并分析了它们各自的优缺点。我们的结果表明，诸如毛囊供应有限、毛囊存活率不理想以及复发性脱发等挑战阻碍了移植的有效性，使得许多患者对现有选择不满意。幸运的是，再生医学的进展，特别是源自诱导多能干细胞的单细胞整合毛囊或皮肤类器官的发展，提供了有前景的替代方案。这些创新有可能提供大量根据个体患者特定需求定制的均匀毛囊，从而为那些传统方法治疗效果不佳的患者扩大治疗选择。总之，除了有限的局部和全身治疗方法外，植发往往是脱发患者的最后手段。生成新毛囊或类器官的潜力预示着大规模临床应用和标准化治疗方案建立的新时代。
