高流行地区隐匿性乙肝病毒感染状况：社区乙肝病毒传播及再激活风险
The status of occult HBV infection in a high endemic region: risk of community HBV transmission and reactivation.
作者信息
Kafeero Hussein Mukasa, Ocama Ponsiano, Ndagire Dorothy, Walusansa Abdul, Namusoke Mariam, Kudamba Ali, Muwanda Fahad, Sendagire Hakim
机构信息
Department of Biomedical and Mechatronics Engineering, Kyambogo University, P.O Box 1, Kyambogo, Uganda.
Department of Medicine, College of Health Sciences, Makerere University, P.O Box 7062, Kampala, Uganda.
出版信息
BMC Res Notes. 2025 Jul 1;18(1):255. doi: 10.1186/s13104-025-07337-6.
OBJECTIVES
Occult hepatitis B virus (OBI) infection, characterized by the presence of HBV DNA in the absence of detectable HBsAg in the blood, is considered a potential hidden pathway for HBV transmission and reactivation, which can lead to liver cancer. This study aimed to assess the prevalence of OBI in a region of Uganda with high HBV endemicity, in order to help explain variations in HBV distribution within the country.
RESULTS
Among the 387 participants who tested negative for HBsAg, the majority were women (240 individuals, 62.0%), married (242 individuals, 62.5%), and aged 30 years or older (207 individuals, 53.5%). The OBI was detected in 21 participants (5.43%). Most of those with OBI were 30 years old or younger (13 individuals, 61.9%), male (12 individuals, 57.1%), had normal liver enzyme levels, and showed an average viral load of 194.4 IU/mL with a standard deviation (SD) of ± 122.05.
目的
隐匿性乙型肝炎病毒（OBI）感染的特征是血液中存在HBV DNA但检测不到HBsAg，被认为是HBV传播和再激活的潜在隐匿途径，可导致肝癌。本研究旨在评估乌干达一个HBV高流行地区的OBI患病率，以帮助解释该国HBV分布的差异。
结果
在387名HBsAg检测呈阴性的参与者中，大多数为女性（240人，62.0%）、已婚（242人，62.5%）且年龄在30岁及以上（207人，53.5%）。21名参与者（5.43%）检测到OBI。大多数OBI感染者年龄在30岁及以下（13人，61.9%）、男性（12人，57.1%），肝酶水平正常，平均病毒载量为194.4 IU/mL，标准差（SD）为±122.05。
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