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2025年韩国甲状腺协会低风险乳头状甲状腺癌主动监测临床管理指南

2025 Korean Thyroid Association Clinical Management Guideline on Active Surveillance for Low-Risk Papillary Thyroid Carcinoma.

作者信息

Lee Eun Kyung, Kim Min Joo, Kang Seung Heon, Koo Bon Seok, Kim Kyungsik, Kim Mijin, Kim Bo Hyun, Kim Ji-Hoon, Moon Shinje, Back Kyorim, Song Young Shin, Ahn Jong-Hyuk, Ahn Hwa Young, Won Ho-Ryun, Yoo Won Sang, Lee Min Kyoung, Lee Jeongmin, Lee Ji Ye, Jung Kyong Yeun, Jung Chan Kwon, Cho Yoon Young, Lim Dong-Jun, Kim Sun Wook, Park Young Joo, Na Dong Gyu, Kim Jee Soo

机构信息

Department of Internal Medicine, Center for Thyroid Cancer, National Cancer Center, Goyang, Korea.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

出版信息

Endocrinol Metab (Seoul). 2025 Jun;40(3):307-341. doi: 10.3803/EnM.2025.2461. Epub 2025 Jun 24.


DOI:10.3803/EnM.2025.2461
PMID:40598902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12230268/
Abstract

The increasing detection of papillary thyroid microcarcinoma (PTMC) has raised concerns regarding overtreatment. For low-risk PTMC, either immediate surgery or active surveillance (AS) can be considered. To facilitate the implementation of AS, the Korean Thyroid Association convened a multidisciplinary panel and developed the first Korean guideline. AS is recommended for adults with pathologically confirmed Bethesda V-VI PTMC who have no clinical evidence of lymph node or distant metastasis, gross extrathyroidal extension, invasion of the trachea or recurrent laryngeal nerve, or aggressive histology. A baseline assessment requires high-resolution neck ultrasound performed by experienced operators to exclude extrathyroidal extension, tracheal or recurrent laryngeal nerve invasion, and lymph node metastasis; contrast-enhanced neck computed tomography is optional. Patient characteristics, including age, comorbidities, and the capacity for long-term follow-up, should be thoroughly assessed. Shared decision-making should carefully weigh the benefits and risks of surgery versus AS, considering expected oncologic outcomes, potential complications, quality of life, anxiety, medical costs, and patient preference. Follow-up involves neck ultrasound and thyroid function tests every 6 months for 2 years and annually thereafter. Disease progression, defined as significant tumor growth or newly detected nodal or distant metastasis, warrants surgery. Despite remaining uncertainties, this guideline provides a structured framework to ensure oncologic safety and supports patient-centered AS.

摘要

甲状腺微小乳头状癌(PTMC)检出率的不断上升引发了对过度治疗的担忧。对于低风险PTMC,可考虑立即手术或主动监测(AS)。为促进AS的实施,韩国甲状腺协会召集了一个多学科小组并制定了首个韩国指南。对于经病理证实为Bethesda V-VI级PTMC且无淋巴结或远处转移、肉眼可见甲状腺外侵犯、气管或喉返神经侵犯或侵袭性组织学临床证据的成年人,推荐采用AS。基线评估需要由经验丰富的操作人员进行高分辨率颈部超声检查,以排除甲状腺外侵犯、气管或喉返神经侵犯以及淋巴结转移;颈部增强计算机断层扫描为可选检查。应全面评估患者特征,包括年龄、合并症以及长期随访能力。共同决策应仔细权衡手术与AS的利弊,考虑预期肿瘤学结果、潜在并发症、生活质量、焦虑程度、医疗费用以及患者偏好。随访包括在2年内每6个月进行一次颈部超声和甲状腺功能检查,此后每年进行一次。疾病进展定义为肿瘤显著生长或新发现的淋巴结或远处转移,此时需要进行手术。尽管仍存在不确定性,但本指南提供了一个结构化框架,以确保肿瘤学安全性并支持以患者为中心的AS。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3cb/12230268/23b3450d7c1a/enm-2025-2461f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3cb/12230268/6e604c67aede/enm-2025-2461f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3cb/12230268/23b3450d7c1a/enm-2025-2461f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3cb/12230268/6e604c67aede/enm-2025-2461f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3cb/12230268/23b3450d7c1a/enm-2025-2461f2.jpg

相似文献

[1]
2025 Korean Thyroid Association Clinical Management Guideline on Active Surveillance for Low-Risk Papillary Thyroid Carcinoma.

Endocrinol Metab (Seoul). 2025-6

[2]
Central neck dissection for papillary thyroid cancer.

Cancer Control. 2011-4

[3]
Indications and Strategy for Active Surveillance of Adult Low-Risk Papillary Thyroid Microcarcinoma: Consensus Statements from the Japan Association of Endocrine Surgery Task Force on Management for Papillary Thyroid Microcarcinoma.

Thyroid. 2021-2

[4]
The Initial Risk Stratification System for Differentiated Thyroid Cancer: Key Updates in the 2024 Korean Thyroid Association Guideline.

Endocrinol Metab (Seoul). 2025-6

[5]
Standardized Ultrasound Evaluation for Active Surveillance of Low-Risk Thyroid Microcarcinoma in Adults: 2024 Korean Society of Thyroid Radiology Consensus Statement.

Korean J Radiol. 2024-11

[6]
BRAF mutation in papillary thyroid cancer and its value in tailoring initial treatment: a systematic review and meta-analysis.

Medicine (Baltimore). 2012-9

[7]
The experience of adults who choose watchful waiting or active surveillance as an approach to medical treatment: a qualitative systematic review.

JBI Database System Rev Implement Rep. 2016-2

[8]
Ultrasound-guided thermal ablation for papillary thyroid microcarcinoma: A systematic review.

Clin Endocrinol (Oxf). 2023-3

[9]
Papillary thyroid microcarcinoma presenting as lymph node metastasis--a diagnostic challenge: case report and systematic review of literature.

Hormones (Athens). 2012

[10]
Multigene Detection Analysis of Multifocal Papillary Thyroid Carcinoma.

Clin Endocrinol (Oxf). 2025-8

本文引用的文献

[1]
2024 International Expert Consensus on US-guided Thermal Ablation for T1N0M0 Papillary Thyroid Cancer.

Radiology. 2025-4

[2]
Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2022.

Cancer Res Treat. 2025-4

[3]
Radiofrequency Ablation of Low-Risk Papillary Thyroid Microcarcinoma: A Retrospective Cohort Study Including Patients with More than 10 Years of Follow-up.

Thyroid. 2025-2

[4]
Outcomes and effectiveness of active surveillance for low-risk papillary thyroid carcinoma: a systematic review and meta-analysis.

Eur Arch Otorhinolaryngol. 2025-5

[5]
A national survey of physicians regarding active surveillance for low-risk thyroid cancer in Korea.

Eur Thyroid J. 2025-1-9

[6]
Cytologic hallmarks and differential diagnosis of papillary thyroid carcinoma subtypes.

J Pathol Transl Med. 2024-11

[7]
Clinical Significance of Gross Extrathyroidal Extension to Only the Strap Muscle According to Tumor Size in Differentiated Thyroid Cancer: A Systematic Review and Meta-Analysis.

Clin Exp Otorhinolaryngol. 2024-11

[8]
Standardized Ultrasound Evaluation for Active Surveillance of Low-Risk Thyroid Microcarcinoma in Adults: 2024 Korean Society of Thyroid Radiology Consensus Statement.

Korean J Radiol. 2024-11

[9]
Implementing active surveillance for low-risk thyroid carcinoma into clinical practice: collaborative recommendations for Latin America.

Arch Endocrinol Metab. 2024

[10]
Comparison of Patient-Reported Outcomes Between Active Surveillance and Immediate Lobectomy in Patients with Low-Risk Papillary Thyroid Microcarcinoma: Initial Findings from the KoMPASS Cohort.

Thyroid. 2024-11

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