Rodrigues Karla Faquine, de Oliveira Thais Cardoso, do Amaral Montanheiro Thaís Larissa, Kito Letícia Terumi, Schatkoski Vanessa Modelski, Dos Santos Alan Silva, Pereira Raissa Monteiro, Boccaccini Aldo Roberto, Thim Gilmar Patrocínio, Unalan Irem
Laboratory of Nanotechnology, Aeronautics Institute of Technology, Sao Jose dos Campos, Brazil.
Institute of Biomaterials, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Int Wound J. 2025 Jul;22(7):e70711. doi: 10.1111/iwj.70711.
Chronic wounds may develop when there is a delay or disturbance in one of the stages of the healing process, presenting challenging financial, clinical, and quality-of-life costs. Therefore, continuous efforts have been made to develop dressings that optimise wound healing. In recent years, nanotechnology has revolutionised wound care, enabling the development of innovative materials with high efficiency that positively impact the healing process. Nanoparticles have been extensively used in wound dressings because of their specific properties, such as a high surface area-to-volume ratio, increased surface reactivity, and improved biocompatibility, representing a unique tissue repair tool. This review article addresses advances in the use of organic nanoparticles in the field of skin regeneration, considering papers published in the last 5 years, and highlighting the effects of this class of materials on the wound healing process. The analysis of the literature shows that the materials being considered are carbon-based and organic materials, including polymeric, cellulosic, lipid, and liposome nanoparticles, which are covered in this review (inorganic nanoparticles are not considered). Furthermore, important aspects to prevent the development of chronic wounds are presented, as well as general characteristics of wounds, the healing process, and their particularities.
当愈合过程的某个阶段出现延迟或干扰时，可能会形成慢性伤口，这会带来具有挑战性的经济、临床和生活质量成本。因此，人们一直在不断努力开发能优化伤口愈合的敷料。近年来，纳米技术给伤口护理带来了变革，使高效创新材料的开发成为可能，这些材料对愈合过程产生积极影响。纳米颗粒因其特殊性质，如高比表面积、增强的表面反应性和改善的生物相容性，已被广泛应用于伤口敷料中，是一种独特的组织修复工具。这篇综述文章探讨了有机纳米颗粒在皮肤再生领域的应用进展，参考了过去5年发表的论文，并强调了这类材料对伤口愈合过程的影响。文献分析表明，所考虑的材料是碳基和有机材料，包括聚合物、纤维素、脂质和脂质体纳米颗粒，本综述涵盖了这些内容（不考虑无机纳米颗粒）。此外，还介绍了预防慢性伤口形成的重要方面，以及伤口的一般特征、愈合过程及其特殊性。
