Dutt Krishneel, Vasudevan Abhinav, Hodge Alexander, Nguyen Tuan L, Srinivasan Ashish R
Department of Gastroenterology and Hepatology, Eastern Health, Box Hill 3128, Victoria, Australia.
Eastern Health Clinical School, Monash University, Box Hill 3128, Victoria, Australia.
World J Gastroenterol. 2025 Jun 28;31(24):107661. doi: 10.3748/wjg.v31.i24.107661.
Metabolic syndrome-comprising central adiposity, dyslipidaemia, insulin resistance, and hypertension-is a major risk factor for cardiometabolic diseases such as ischaemic heart disease, stroke, and type 2 diabetes. Its global prevalence is rising, largely driven by urbanization, sedentary lifestyles, and dietary changes. These same factors are also associated with the increasing incidence of inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis. Emerging evidence supports a potential biological link between chronic gastrointestinal inflammation and the later development of cardiometabolic disorders; a connection that is particularly relevant for patients with IBD. Comparative studies examining cardiometabolic risk associated with Crohn's disease versus ulcerative colitis have reported inconsistent findings, likely due to confounding factors such as age, lifestyle, and comorbidities. This review summarizes current evidence linking IBD and cardiometabolic disorders, and highlights the need for clinicians to recognize cardiometabolic risk in patients with IBD. Future research should investigate whether treat-to-target strategies focused on controlling intestinal inflammation can simultaneously improve both long-term IBD and cardiometabolic outcomes.
代谢综合征包括中心性肥胖、血脂异常、胰岛素抵抗和高血压，是缺血性心脏病、中风和2型糖尿病等心脏代谢疾病的主要危险因素。其全球患病率正在上升，主要由城市化、久坐不动的生活方式和饮食变化驱动。这些相同的因素也与炎症性肠病（IBD）发病率的增加有关，包括克罗恩病和溃疡性结肠炎。新出现的证据支持慢性胃肠道炎症与心脏代谢紊乱后期发展之间存在潜在的生物学联系；这种联系对IBD患者尤为重要。比较研究克罗恩病和溃疡性结肠炎相关心脏代谢风险的结果并不一致，可能是由于年龄、生活方式和合并症等混杂因素。本综述总结了目前将IBD与心脏代谢紊乱联系起来的证据，并强调临床医生需要认识到IBD患者的心脏代谢风险。未来的研究应调查以控制肠道炎症为目标的治疗策略是否能同时改善IBD的长期预后和心脏代谢结局。
