Aslam Mohsin, Norup Pernille Badsberg, Haahr Mette Ewers, Pagsberg Anne Katrine, Giraldi Annamaria, Jørgensen Niels, Main Katharina Maria
Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark.
J Endocr Soc. 2025 Jun 10;9(8):bvaf105. doi: 10.1210/jendso/bvaf105. eCollection 2025 Aug.
Some transgender individuals wish to become biological parents in the future and transfeminine persons may be offered cryopreservation of semen before starting hormone therapy. However, there is a lack of knowledge about semen cryopreservation outcomes among transfeminine adolescents seeking gender-affirming care.
To investigate transfeminine adolescents who decide for or against semen cryopreservation.
This is a retrospective observational national cohort study of 58 transfeminine individuals aged <18 years, assessing clinical data, semen parameters, and reproductive hormone levels.
Among the 58 individuals, 23 (39.7%) opted for semen cryopreservation and successfully collected a semen sample. They were older and more advanced in pubertal development compared with those who did not: median age was 16.4 years (range, 13.7-19.4) vs 15.8 years (11.7-17.9); Tanner stage G5 (4-5) vs G3 (2-4); and testis volume 20 mL (15-25) vs 8 mL (3-20). Among 17 individuals with no prior hormone therapy, the median sperm concentration was 11.1 × 10/mL (0.02-163), semen volume 1.8 mL (0.2-3.9), total sperm count 17.8 × 10 (0.1-214.2), and percentage of progressively motile spermatozoa 46% (8-74). Reproductive hormones were within normal ranges for age and registered sex at birth.
The percentage of adolescents opting for semen cryopreservation was comparable to other countries with a publicly financed national healthcare system. Overall, semen quality was impaired.
一些跨性别者希望未来成为亲生父母，对于跨性别女性，在开始激素治疗前可能会建议进行精液冷冻保存。然而，在寻求性别肯定治疗的跨性别青少年中，对于精液冷冻保存结果缺乏了解。
调查决定进行或不进行精液冷冻保存的跨性别青少年。
这是一项针对58名年龄小于18岁的跨性别女性的回顾性观察全国队列研究，评估临床数据、精液参数和生殖激素水平。
在这58名个体中，23名（39.7%）选择进行精液冷冻保存并成功采集到精液样本。与未选择的个体相比，他们年龄更大且青春期发育更成熟：中位年龄为16.4岁（范围13.7 - 19.4岁），而未选择者为15.8岁（11.7 - 17.9岁）； Tanner分期为G5（4 - 5期），而未选择者为G3（2 - 4期）；睾丸体积为20 mL（15 - 25），而未选择者为8 mL（3 - 20）。在17名未接受过激素治疗的个体中，中位精子浓度为11.1×10⁶/mL（0.02 - 163），精液量为1.8 mL（0.2 - 3.9），总精子数为17.8×10⁶（0.1 - 214.2），进行性运动精子百分比为46%（8 - 74）。生殖激素处于出生时登记性别的年龄正常范围内。
选择精液冷冻保存的青少年比例与其他拥有公共资助国家医疗保健系统的国家相当。总体而言，精液质量受损。
