Borelli-Kjær Anna, Aksglaede Lise, Jensen Rikke Beck, Hagen Casper Petri, Ljubicic Marie Lindhardt, Busch Alexander Siegfried, Upners Emmie Nicolina, Fischer Margit Bistrup, Jensen Tina Kold, Linneberg Allan, Kårhus Line Lund, Andersson Anna-Maria, Petersen Jørgen Holm, Juul Anders, Johannsen Trine Holm
Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, DK-2100 Copenhagen, Denmark.
International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark.
J Clin Endocrinol Metab. 2024 Dec 18;110(1):70-77. doi: 10.1210/clinem/dgae439.
To describe the natural history of inhibin B throughout life according to sex, age, and pubertal development.
Based on serum samples from 2707 healthy controls aged 0 to 80 years, sex- and age-specific reference ranges of inhibin B concentrations were constructed. Concentrations were evaluated according to pubertal development and use of oral contraceptives (OCs). Also, measurements from 42 patients with Klinefelter syndrome were included.
In both sexes, inhibin B concentrations were high during minipuberty, decreased in childhood, and significantly increased from Tanner stages B1 to B3 (peak: B4) in females and from G1 to G3 (peak: G3) in males. Despite variations in menstruating females, inhibin B concentrations remained relatively constant after puberty until becoming unmeasurable at menopause. Despite a modest decrease, the inhibin B concentration in males remained relatively high from puberty onward. At any age, males had highest concentrations. Inhibin B SD scores were lower in OC users (median SD score = -0.88) than in nonusers (SD score = 0.35), P < .001. In patients with Klinefelter syndrome, inhibin B concentrations spanned the reference range until approximately 15 years of age, where they decreased to subnormal or unmeasurable levels.
Valuable sex- and age-specific reference data for inhibin B concentrations were provided. In OC users, decreased concentrations of inhibin B underlined the ovaries as the only place of inhibin B production. In patients with Klinefelter syndrome, the decline in inhibin B concentrations at puberty underlined the shift in regulation of inhibin B production at pubertal onset.
根据性别、年龄和青春期发育情况描述抑制素B在一生中的自然史。
基于2707名年龄在0至80岁的健康对照者的血清样本，构建了抑制素B浓度的性别和年龄特异性参考范围。根据青春期发育情况和口服避孕药（OC）的使用情况评估浓度。此外，还纳入了42例克兰费尔特综合征患者的测量数据。
在男女两性中，抑制素B浓度在小青春期时较高，在儿童期降低，在女性从坦纳分期B1到B3（峰值：B4）以及男性从G1到G3（峰值：G3）时显著升高。尽管月经周期中的女性存在差异，但抑制素B浓度在青春期后保持相对稳定，直到绝经时无法测量。尽管有适度下降，但男性的抑制素B浓度从青春期开始一直保持相对较高。在任何年龄，男性的浓度最高。口服避孕药使用者的抑制素B标准差评分（中位数标准差评分 = -0.88）低于非使用者（标准差评分 = 0.35），P <.001。在克兰费尔特综合征患者中，抑制素B浓度在大约15岁之前处于参考范围内，之后降至低于正常或无法测量的水平。
提供了关于抑制素B浓度的有价值的性别和年龄特异性参考数据。在口服避孕药使用者中，抑制素B浓度降低突出了卵巢是抑制素B产生的唯一部位。在克兰费尔特综合征患者中，青春期抑制素B浓度的下降突出了青春期开始时抑制素B产生调节的转变。
