Xu Ye, Yang Xinxin, Wang Fei, Wu Dongbo, Sun Jianghong, Meng Hongxue, Zhang Xiushi
Department of Radiology, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin 150081, Heilongjiang, China.
Precision Medical Center, Department of Pathology, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin 150081, Heilongjiang, China.
Breast J. 2025 Jun 24;2025:2793342. doi: 10.1155/tbj/2793342. eCollection 2025.
To investigate the association between mammographic extratumoral signs, specifically their subclassifications, of nonspiculate and noncalcified masses (NSNCMs) and prognostic factors in breast cancer. This retrospective study analyzed imaging and pathological data from 374 patients, categorizing extratumoral signs into structural abnormalities (parenchymal and trabecular) and halo, while also undergoing subclassification. The focus prognostic factors were achieved through screening. Then, univariate and multivariate analyses were performed. Correlation analysis was also employed to determine the relationship between subclassifications and prognostic factors. Lymphovascular invasion (LVI), Ki-67 levels, and stromal tumor-infiltrating lymphocytes (sTIL) levels were identified as the focus prognostic factors. Among tumor signs, only tumor margin was associated with sTIL levels. Extratumoral trabecular signs exhibited a significant correlation with LVI (OR = 2.5, =0.007) and Ki-67 levels (OR = 1.23, =0.001). Specifically, the parallel sign showed a positive correlation with LVI (=0.009, = 0.134), while the reticular sign displayed a positive correlation with Ki-67 levels (=0.009, = 0.134). Extratumoral parenchymal signs were found to be an independent predictor for sTIL levels (OR = 0.64, < 0.001), with a negative correlation observed between the contraction sign and sTIL levels ( < 0.001, = -0.185), as well as between the atrophy sign and sTIL levels (=0.046, = -0.103). Specific extratumoral structural abnormalities of mammographic malignant NSNCMs showed a significant correlation with prognostic factors in breast cancer, warranting increased attention in research and clinical practice.
研究乳腺钼靶检查中肿瘤外体征，特别是其亚分类，与非毛刺状和非钙化肿块（NSNCMs）的乳腺癌预后因素之间的关联。这项回顾性研究分析了374例患者的影像和病理数据，将肿瘤外体征分为结构异常（实质和小梁）和晕征，并进行了亚分类。通过筛查确定重点预后因素。然后进行单因素和多因素分析。还采用相关分析来确定亚分类与预后因素之间的关系。确定血管淋巴管浸润（LVI）、Ki-67水平和基质肿瘤浸润淋巴细胞（sTIL）水平为重点预后因素。在肿瘤体征中，只有肿瘤边缘与sTIL水平相关。肿瘤外小梁征与LVI（OR = 2.5，P = 0.007）和Ki-67水平（OR = 1.23，P = 0.001）呈显著相关。具体而言，平行征与LVI呈正相关（P = 0.009，r = 0.134），而网状征与Ki-67水平呈正相关（P = 0.009，r = 0.134）。发现肿瘤外实质征是sTIL水平的独立预测因素（OR = 0.64，P < 0.001），收缩征与sTIL水平之间呈负相关（P < 0.001，r = -0.185），萎缩征与sTIL水平之间也呈负相关（P = 0.046，r = -0.103）。乳腺钼靶恶性NSNCMs的特定肿瘤外结构异常与乳腺癌预后因素呈显著相关，值得在研究和临床实践中给予更多关注。
