Evaluating the relationship between familial poverty, seropositivity, and all-cause mortality in the general US population.

PURPOSE

Socioeconomic inequality is closely related to the incidence of () infection and mortality outcomes. Accordingly, this study was designed with the goal of exploring the relationship between familial poverty, seropositivity, and all-cause mortality among adults in the United States.

METHODS

Data from National Health and Nutrition Examination Survey (1999-2000) was used to conduct analysis. Family poverty to income ratio (PIR) was applied to evaluate socioeconomic status. The interplay between serostatus and PIR was evaluated through univariate and multivariable approaches. The relationship between PIR, serostatus, and the incidence of all-cause mortality was further assessed through Cox regression analysis, restricted cubic spline, and survival analysis.

RESULTS

A total of 3,573 individuals were included in this study. PIR values were found to be negatively associated with seropositivity incidence after adjusting for potential covariates. Smooth curve fitting suggested that the relationship between these two variables was largely linear. Subgroup analyses confirmed that PIR values were still closely associated with seropositivity independently. Moreover, multivariate Cox regression analysis demonstrated that lower PIR was associated with an increase in all-cause mortality in both seropositivity and seronegative group, whereas serostatus showed no association with all-cause mortality. Additional analysis using smooth curve fitting indicated a nonlinear relationship between PIR and all-cause mortality. The survival analysis further indicated that individuals with higher PIR values exhibited lower mortality rates, regardless of serostatus.

CONCLUSION

The present analyses reveal an inverse association between PIR values and seropositivity and all-cause mortality. The relationship between PIR and all-cause mortality was not affected by seropositivity. serostatus is not a major risk factor for all-cause mortality. However, additional studies will be essential to better clarify the clinical relevance of these findings and to elucidate the underlying findings.