Young L H, Kim S B, Takhar J S, Sun L D, White K M, Omar A F
Case Western Reserve University School of Medicine. Cleveland, OH, USA.
University Hospitals Cleveland Medical Center, Department of Ophthalmology. Cleveland, OH, USA.
Am J Ophthalmol Case Rep. 2025 Jun 7;39:102363. doi: 10.1016/j.ajoc.2025.102363. eCollection 2025 Sep.
To present an atypical case of reactive infectious mucocutaneous eruption (RIME) in an adult patient attributed to primary adenoviral infection.
This is a case describing the clinical course of a previously healthy 34-year old man who presented with acute onset urethritis and bilateral conjunctivitis. His left eye conjunctivitis progressed to pseudomembrane and symblepharon formation within days. His clinical course was marked by progressive worsening of urethritis and formation of mucus membrane ulceration and bullae even after antibiotic treatment and aggressive topical lubrication. He required admission and a multidisciplinary team made the diagnosis of adenovirus-induced RIME. He was treated with intravenous steroids and intravenous cyclosporine. He ultimately recovered with a good visual outcome.
This case demonstrates a rare case of RIME in an adult triggered by an adenovirus infection. Multidisciplinary care is key to diagnosis and treatment.
报告一例成年患者因原发性腺病毒感染导致的反应性感染性皮肤黏膜疹（RIME）非典型病例。
本病例描述了一名既往健康的34岁男性的临床病程，该患者急性起病，出现尿道炎和双侧结膜炎。其左眼结膜炎在数天内进展为假膜形成和睑球粘连。即使经过抗生素治疗和积极的局部润滑，其临床病程仍以尿道炎进行性加重以及黏膜溃疡和大疱形成为特征。他需要住院治疗，一个多学科团队诊断为腺病毒诱导的RIME。他接受了静脉注射类固醇和静脉注射环孢素治疗。最终他康复，视力恢复良好。
本病例显示了由腺病毒感染引发的成人RIME罕见病例。多学科护理是诊断和治疗的关键。
