Bhatia Ashish C, Napekoski Karl, Edgecombe Jill, Weir David, Winkle Rachelle, Rohrich Rod
Associate Professor of Clinical Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Adjunct Associate Professor of Clinical Dermatology, Rush University School of Medicine, Chicago, Illinois, USA.
J Cosmet Dermatol. 2025 Jul;24(7):e70323. doi: 10.1111/jocd.70323.
Mechanical Dermal Micro-Coring Technology (MCT; Ellacor System) achieves skin tightening and wrinkle reduction through direct mechanical excision of skin cores using hollow needles and collagen stimulation via the wound-healing response.
To evaluate histopathology and immunohistochemistry of the skin and subcutaneous tissue after a single and multiple treatments with MCT.
PATIENTS/METHODS: In this single-center pilot study, 6 female patients scheduled to undergo abdominoplasty were divided into 2 cohorts. Subjects in cohort 1 (safety cohort) received 1 MCT treatment at a depth of 4 mm, 5 mm, and 7 mm, each administered at 1 of 3 unique test areas, with tissue sampling/abdominoplasty 30 days after treatment. Subjects in cohort 2 received 1, 2, or 3 4 mm-depth treatments at 1 of 3 unique test sites, with 30-day intervals for > 1 treatment. Tissue sampling/abdominoplasty occurred 90 days after initial treatment. Histopathology was performed at a central laboratory, and biopsies were evaluated using H&E, Herovici, and Movat stains by blinded evaluators.
A robust increase in new collagen compared to the control tissue was observed for 1 to 3 treatments in all samples. There was no evidence of inflammation or scarring, consistent with earlier preclinical and clinical histology.
MCT-associated histological changes confirm that in addition to skin removal, treatment results in an increase in collagen and homogenization of the dermis in the treated area.
机械性真皮微取芯技术（MCT；Ellacor系统）通过使用空心针直接机械切除皮肤芯，并通过伤口愈合反应刺激胶原蛋白，从而实现皮肤紧致和减少皱纹。
评估单次和多次MCT治疗后皮肤和皮下组织的组织病理学和免疫组织化学情况。
患者/方法：在这项单中心前瞻性研究中，6名计划接受腹部整形手术的女性患者被分为2组。第1组（安全组）在3个不同的测试区域之一分别接受深度为4毫米、5毫米和7毫米的1次MCT治疗，治疗后30天进行组织取样/腹部整形手术。第2组在3个不同的测试部位之一接受1次、2次或3次深度为4毫米的治疗，若进行多次治疗，每次治疗间隔30天。在首次治疗后90天进行组织取样/腹部整形手术。组织病理学检查在中央实验室进行，活检标本由不知情的评估人员使用苏木精-伊红染色、赫罗维奇染色和莫瓦特染色进行评估。
在所有样本中，与对照组织相比，1至3次治疗后新胶原蛋白均显著增加。没有炎症或瘢痕形成的迹象，这与早期的临床前和临床组织学结果一致。
与MCT相关的组织学变化证实，除了去除皮肤外，该治疗还能使治疗区域的胶原蛋白增加，真皮均匀化。
