Spaun E, Midholm S, Pedersen N T, Ringsted J
Surg Neurol. 1985 Dec;24(6):646-50. doi: 10.1016/0090-3019(85)90123-5.
The occurrence of primary malignant lymphomas of the central nervous system in a population of approximately 1 million people has been analyzed retrospectively. Over a 12-year period, about 1000 tumors of the central nervous system were registered. Among these, 22 were primary malignant lymphomas; incidence, 1.83 per million per year. Thirteen of these tumors were of high-grade malignancy and nine were of low-grade malignancy (Kiel classification of non-Hodgkin lymphomas). The majority of the tumors were B-cell lymphomas, and there were no Hodgkin lymphomas. Neither spinal nor meningeal lymphomas occurred. Nine patients were treated only surgically, whereas 11 received postoperative irradiation or chemotherapy, or both. Of the latter patients, six are alive and well at the time of writing. The importance of making a correct diagnosis preoperatively is stressed, inasmuch as radical operation is unfavorable for these patients. A better prognosis is obtained with combinations of irradiation and chemotherapy.
对约100万人口中发生的原发性中枢神经系统恶性淋巴瘤进行了回顾性分析。在12年期间，登记了约1000例中枢神经系统肿瘤。其中，22例为原发性恶性淋巴瘤；发病率为每年每百万1.83例。这些肿瘤中13例为高度恶性，9例为低度恶性（非霍奇金淋巴瘤的基尔分类）。大多数肿瘤为B细胞淋巴瘤，无霍奇金淋巴瘤。未发生脊髓或脑膜淋巴瘤。9例患者仅接受了手术治疗，而11例接受了术后放疗或化疗，或两者皆有。在撰写本文时，后一组患者中有6例存活且状况良好。强调术前做出正确诊断的重要性，因为根治性手术对这些患者不利。放疗和化疗联合应用可获得更好的预后。
