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小儿精索静脉曲张栓塞术:一家三级中心14年的临床经验、见解及长期临床结果——一项队列研究

Paediatric Varicocele Embolisation: Clinical Experience, Insights and Long Term Clinical Outcomes Over 14 Years at a Tertiary Centre-A Cohort Study.

作者信息

Lau Fiona S, Pereira John K, Jiwane Ashish, McGregor Priya

机构信息

Department of Medical Imaging, Campus Centre, Prince of Wales & Sydney Children's Hospitals, Randwick, New South Wales, Australia.

University of New South Wales, Kensington, New South Wales, Australia.

出版信息

J Med Imaging Radiat Oncol. 2025 Sep;69(6):662-667. doi: 10.1111/1754-9485.13878. Epub 2025 Jul 2.

DOI:10.1111/1754-9485.13878
PMID:40600623
Abstract

INTRODUCTION

Varicocele is a correctable cause of male infertility with management options including catheter embolisation of the testicular vein, done by Interventional Radiologists. Varicoceles can present in childhood and adolescence with scrotal pain or discomfort, or may be subclinical. It involves dilatation of the pampiniform plexus related to congestion and retrograde flow in the testicular vein. If left untreated, the pain and discomfort may impact the quality of life of the paediatric patient, and in the long term, infertility may ensue. However, limited data are available on the long-term clinical outcomes and complications of Varicocele embolisation in paediatric patients.

METHOD

Retrospective cohort study of 14 years of endovascular Varicocele embolisation at a single-operator tertiary paediatric centre.

RESULTS

Eighty-four patients with a median age of 14 years (range 8-17 years) were identified. The varicoceles were predominantly of grade 1 or 2. 99% of patients had unilateral left-sided varicoceles. One patient had bilateral varicoceles. This study demonstrated that the technical success rate of endovascular embolisation is 94% and the clinical success rate is 98%. 84% reported feeling well in the immediate postprocedural period. 86% of cases reported excellent long-term progress. A small proportion (10%) experienced long-term discomfort or pain. There were no cases of relapse.

CONCLUSION

Endovascular embolisation is a successful technique for the management of Varicocele in paediatric patients, with good immediate and long-term clinical outcomes. It has low recurrence rates.

摘要

引言

精索静脉曲张是男性不育的一个可纠正病因,其治疗选择包括由介入放射科医生进行的睾丸静脉导管栓塞术。精索静脉曲张可在儿童期和青春期出现阴囊疼痛或不适,也可能是亚临床的。它涉及蔓状静脉丛的扩张,与睾丸静脉的充血和逆流有关。如果不治疗,疼痛和不适可能会影响儿科患者的生活质量,从长远来看,可能会导致不育。然而,关于儿科患者精索静脉曲张栓塞术的长期临床结果和并发症的数据有限。

方法

对一家三级儿科中心单一操作者进行的14年血管内精索静脉曲张栓塞术进行回顾性队列研究。

结果

确定了84例患者,中位年龄为14岁(范围8 - 17岁)。精索静脉曲张主要为1级或2级。99%的患者为单侧左侧精索静脉曲张。1例患者为双侧精索静脉曲张。本研究表明,血管内栓塞术的技术成功率为94%,临床成功率为98%。84%的患者在术后即刻感觉良好。86%的病例报告长期进展良好。一小部分(10%)患者经历了长期不适或疼痛。没有复发病例。

结论

血管内栓塞术是治疗儿科患者精索静脉曲张的一种成功技术,具有良好的近期和长期临床效果。其复发率低。

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本文引用的文献

1
A cost outcome study of varicocoele embolisation and future pregnancy in an Australian public hospital setting.澳大利亚公立医院精索静脉曲张栓塞术与未来妊娠的成本-结局研究。
J Med Imaging Radiat Oncol. 2024 Apr;68(3):282-288. doi: 10.1111/1754-9485.13629. Epub 2024 Mar 4.
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10-year experience of Paediatric varicocele embolization in a tertiary centre with long-term follow-up.10 年小儿精索静脉曲张栓塞治疗经验:来自一家三级中心的长期随访结果。
J Pediatr Urol. 2022 Apr;18(2):113.e1-113.e6. doi: 10.1016/j.jpurol.2021.12.013. Epub 2021 Dec 28.
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Varicocele and Testicular Pain: A Review.
精索静脉曲张与睾丸疼痛:综述
World J Mens Health. 2019 Jan;37(1):4-11. doi: 10.5534/wjmh.170010. Epub 2018 May 16.
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Varicocele and male infertility.精索静脉曲张与男性不育。
Nat Rev Urol. 2017 Sep;14(9):523-533. doi: 10.1038/nrurol.2017.98. Epub 2017 Jul 4.
5
Redefining the Criteria for Grading Varicoceles Based on Reflux Times: A Clinicoradiological Correlation.基于反流时间重新定义精索静脉曲张分级标准:临床与放射学相关性研究
Ultrasound Q. 2016 Mar;32(1):82-5. doi: 10.1097/RUQ.0000000000000168.
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Cost-effectiveness analysis reveals microsurgical varicocele repair is superior to percutaneous embolization in the treatment of male infertility.成本效益分析显示,在治疗男性不育症方面,显微外科精索静脉曲张修复术优于经皮栓塞术。
Can Urol Assoc J. 2014 Sep;8(9-10):E619-25. doi: 10.5489/cuaj.1873.
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The varicocele.精索静脉曲张。
Urol Clin North Am. 2014 Feb;41(1):129-44. doi: 10.1016/j.ucl.2013.08.001.
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Focus on paediatric and adolescent varicocoele: a single institution experience.关注小儿及青少年精索静脉曲张:单机构经验
Int J Androl. 2012 Oct;35(5):700-5. doi: 10.1111/j.1365-2605.2012.01283.x. Epub 2012 Jun 19.
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Persistent or recurrent varicocoele after failed varicocoelectomy: outcome in patients treated using percutaneous transcatheter embolization.精索静脉结扎术后持续性或复发性精索静脉曲张:经皮经导管栓塞治疗患者的结局。
Clin Radiol. 2012 Apr;67(4):359-65. doi: 10.1016/j.crad.2011.10.007. Epub 2011 Dec 3.
10
The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents.
BJU Int. 2000 Sep;86(4):490-3. doi: 10.1046/j.1464-410x.2000.00735.x.