Tang Zhongyu, Gan Tianmei, Dan Nianhua, Chen Yining
Key Laboratory of Leather Chemistry and Engineering, Sichuan University, Ministry of Education, Sichuan, Chengdu 610065, China.
National Engineering Research Center of Clean Technology in Leather Industry, Sichuan University, Sichuan, Chengdu 610065, China.
ACS Appl Bio Mater. 2025 Jul 21;8(7):6215-6230. doi: 10.1021/acsabm.5c00718. Epub 2025 Jul 2.
Hemorrhages occur frequently in both extreme situations and daily life, necessitating effective hemostatic materials for severe and minor wounds. While collagen is widely used for its biocompatibility and absorbability, its limited thermal stability and efficacy restrict its performance. To address this, we enhanced collagen by modifying it with oxidized extract (OSo), creating OSo-Col (OC) composites. The optimized OC-1.3 composite demonstrated exceptional clotting ability, achieving a blood clotting index of 5.44 ± 0.34% and a clotting time of 5.56 ± 0.82 s in lab tests. In rat models, OC-1.3 reduced liver bleeding time to 30.99 ± 2.47 s and tail amputation bleeding to 18.05 ± 0.63 s, while cutting blood loss to 127.03 ± 42.28 mg─outperforming commercial gauze. These results highlight OC-1.3's potential as a rapid, lightweight solution for both clinical and everyday wound care.
出血在极端情况和日常生活中都经常发生，因此需要有效的止血材料来处理严重和轻微伤口。虽然胶原蛋白因其生物相容性和可吸收性而被广泛使用，但其有限的热稳定性和功效限制了其性能。为了解决这个问题，我们通过用氧化提取物（OSo）对胶原蛋白进行改性来增强它，从而制备出OSo-胶原蛋白（OC）复合材料。优化后的OC-1.3复合材料表现出卓越的凝血能力，在实验室测试中，其凝血指数达到5.44±0.34%，凝血时间为5.56±0.82秒。在大鼠模型中，OC-1.3将肝脏出血时间缩短至30.99±2.47秒，断尾出血时间缩短至18.05±0.63秒，同时将失血量减少至127.03±42.28毫克，优于商用纱布。这些结果凸显了OC-1.3作为一种快速、轻便的解决方案在临床和日常伤口护理中的潜力。
