Choi Won Seok, Park Young Suk, Kim Kun Yung, Lee Chong-Ho, Kim Minuk, Yoon Chang Jin, Lee Jae Hwan
Seoul National University Bundang Hospital, Seongnam, South Korea.
Seoul Metropolitan Boramae Hospital, Seoul National University Seoul Metropolitan Government Boramae Medical Center, Seoul, South Korea.
CVIR Endovasc. 2025 Jul 2;8(1):56. doi: 10.1186/s42155-025-00556-9.
Obesity is a global health challenge, leading researchers to explore innovative treatments. Bariatric arterial embolization (BAE), which blocks blood flow to parts of the stomach, shows promise for weight management by affecting hunger hormones like ghrelin. This study aimed to compare the efficacy and safety of n-butyl-2-cyanoacrylate (NBCA) and microspheres in suppressing weight gain and ghrelin expression after BAE in a swine model.
Fifteen healthy juvenile male farm pigs were randomly allocated into three groups: NBCA embolization (n = 5), microsphere embolization (n = 5), and a control group (n = 5). Embolization targeted the right, left, and short gastric arteries. Weight and fasting plasma ghrelin levels were monitored weekly for 16 weeks. Gastric endoscopy was performed 1 and 4 weeks post-BAE, and each animal's ghrelin-expressing cells in the stomach's fundus, body, and antrum were analyzed.
By week 16, the NBCA group showed lower weight gain (58.4 ± 17.8%) compared to that in the microsphere (114.0 ± 0.0%; P < .001) and control groups (123.9 ± 18.1%; P < .001). The NBCA group had lower mean ghrelin-expressing cell densities in the gastric fundus (P < .001), body (P = .002), and antrum (P = 0.003) compared to those in the control group, and lower ghrelin-expressing cell densities in the fundus compared to those in the microsphere group (P < .001). Endoscopy at 1-week post-BAE revealed gastric ulcers in 2 pigs in the NBCA group (40%) and all pigs (100%) in the microsphere group, which healed by week 4; no ulcers were found in the control group.
In a swine model of bariatric arterial embolization, NBCA was more effective than microspheres in reducing weight gain and ghrelin expression in the stomach fundus, indicating its potential for managing obesity through BAE.
肥胖是一项全球性的健康挑战，促使研究人员探索创新疗法。减重动脉栓塞术（BAE）可阻断胃部部分区域的血流，通过影响胃饥饿素等饥饿激素，在体重管理方面展现出前景。本研究旨在比较正丁基-2-氰基丙烯酸酯（NBCA）和微球在猪模型中进行BAE后抑制体重增加和胃饥饿素表达方面的疗效和安全性。
15只健康的幼年雄性农场猪被随机分为三组：NBCA栓塞组（n = 5）、微球栓塞组（n = 5）和对照组（n = 5）。栓塞目标为胃右动脉、胃左动脉和胃短动脉。每周监测体重和空腹血浆胃饥饿素水平，持续16周。在BAE后1周和4周进行胃镜检查，并分析每只动物胃底、胃体和胃窦中表达胃饥饿素的细胞。
到第16周时，与微球组（114.0±0.0%；P < 0.001）和对照组（123.9±18.1%；P < 0.001）相比，NBCA组体重增加更低（58.4±17.8%）。与对照组相比，NBCA组胃底（P < 0.001）、胃体（P = 0.002）和胃窦（P = 0.003）中表达胃饥饿素的细胞平均密度更低，且与微球组相比，胃底中表达胃饥饿素的细胞密度更低（P < 0.001）。BAE后1周的胃镜检查显示，NBCA组有2头猪（40%）出现胃溃疡，微球组所有猪（100%）出现胃溃疡，这些溃疡在第4周愈合；对照组未发现溃疡。
在减重动脉栓塞术的猪模型中，NBCA在减轻体重增加和胃底胃饥饿素表达方面比微球更有效，表明其通过BAE管理肥胖的潜力。
