Taaning E, Morling N, Ovesen H, Svejgaard A
Tissue Antigens. 1985 Aug;26(2):143-6. doi: 10.1111/j.1399-0039.1985.tb00947.x.
The first two cases of post transfusion purpura (PTP) due to recognized antibodies against the platelet specific antigen Zwb (P1A1) are described. In both cases, the antibodies were detectable in the platelet enzyme immuno-assay (ELISA), while the platelet specific alloantibodies could be ascertained neither in the platelet suspension immunofluorescence test (PSIFT) nor in the platelet fixation test (CFT) due to coexisting potent multispecific HLA-antibodies. The two sera reacted in parallel (coefficient of correlation, r = 0.87; P less than 10(-5) and the reactions of the two sera were negatively associated with the Zwa-antigen (P = 0.0002 and 0.003, respectively). Thus, PTP may be caused not only by anti-Zwa (-P1A1) but also by anti-Zwb.
本文描述了首例因针对血小板特异性抗原Zwb（P1A1）的已知抗体而导致的输血后紫癜（PTP）病例。在这两例病例中，通过血小板酶免疫测定（ELISA）可检测到抗体，但由于同时存在强效多特异性HLA抗体，在血小板悬浮免疫荧光试验（PSIFT）和血小板固定试验（CFT）中均未检测到血小板特异性同种抗体。两份血清反应呈平行关系（相关系数，r = 0.87；P < 10^(-5)），且两份血清的反应与Zwa抗原呈负相关（分别为P = 0.0002和0.003）。因此，PTP不仅可能由抗Zwa（-P1A1）引起，也可能由抗Zwb引起。
