醋酸乙烯酯：体内DNA结合测定
Vinyl acetate: DNA-binding assay in vivo.
作者信息
Simon P, Ottenwälder H, Bolt H M
出版信息
Toxicol Lett. 1985 Sep;27(1-3):115-20. doi: 10.1016/0378-4274(85)90128-6.
PMID:4060182
Abstract
The question of carcinogenicity of vinyl acetate led us to perform a DNA binding assay in vivo in rats, using 14C-labelled vinyl acetate. After administration of [14C]vinyl acetate to male and female Fischer-344 rats, either orally or by inhalation, no specific hepatic DNA adducts, known to occur after administration of labelled vinyl halides or vinyl carbamates, could be detected in hepatic tissues.
摘要
醋酸乙烯酯的致癌性问题促使我们使用14C标记的醋酸乙烯酯在大鼠体内进行DNA结合试验。给雄性和雌性Fischer-344大鼠口服或吸入[14C]醋酸乙烯酯后，在肝脏组织中未检测到已知在给予标记的卤代乙烯或乙烯基氨基甲酸盐后会出现的特异性肝脏DNA加合物。
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