Bastomsky C H
Can J Physiol Pharmacol. 1977 Apr;55(2):288-92. doi: 10.1139/y77-041.
Rats fed a polychlorinated biphenyl (PCB) mixture in a high- or low-iodine diet (HID or LID respectively) for 15 days had thyroid enlargement, low serum thyroxine (T4), and high serum thyrotropin concentrations. Although binding of thyroid hormones to serum proteins was reduced in PCB-fed animals, the free T4 index (reflecting free T4 in serum) was less in these rats. Both serum triiodothyronine (T3) and the free T3 index were elevated in rats fed PCB in HID. LID-maintained rats elevated serum T3 concentrations but the free T3 index was similar to that in HID-fed rats, owing to enhanced binding of thyroid hormone to serum proteins. Addition of PCB to LID reduced serum T3 levels but did not alter the free T3 index because binding was less. In rats fed HID containing PCB, thyroid 131I uptake was increased.
分别在高碘或低碘饮食（分别为HID或LID）中喂食多氯联苯（PCB）混合物15天的大鼠出现甲状腺肿大、血清甲状腺素（T4）降低和血清促甲状腺素浓度升高。尽管喂食PCB的动物中甲状腺激素与血清蛋白的结合减少，但这些大鼠的游离T4指数（反映血清中的游离T4）较低。在HID中喂食PCB的大鼠血清三碘甲状腺原氨酸（T3）和游离T3指数均升高。维持LID的大鼠血清T3浓度升高，但游离T3指数与喂食HID的大鼠相似，这是由于甲状腺激素与血清蛋白的结合增强。向LID中添加PCB可降低血清T3水平，但由于结合减少，并未改变游离T3指数。在喂食含PCB的HID的大鼠中，甲状腺131I摄取增加。
