Federico Giorgia, Moccia Marialuisa, Carlomagno Francesca
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Federico II, Napoli, Italy.
Istituto di Endocrinologia e Oncologia Sperimentale del CNR, Napoli, Italy.
Adv Exp Med Biol. 2025;1480:61-73. doi: 10.1007/978-3-031-92033-2_5.
Iron is an essential micronutrient that supports cellular pathways such as DNA replication, metabolism, oxygen transport and oxidative phosphorylation via reduction-oxidation reactions. Nevertheless, in specific conditions, iron can be deleterious since it promotes different types of unprogrammed and programmed cell death, including apoptosis, necroptosis, and ferroptosis. In this chapter, we will address the role of iron in promoting cell death and the signaling pathways involved.
铁是一种必需的微量营养素，它通过氧化还原反应支持细胞途径，如DNA复制、代谢、氧气运输和氧化磷酸化。然而，在特定条件下，铁可能是有害的，因为它会促进不同类型的非程序性和程序性细胞死亡，包括凋亡、坏死性凋亡和铁死亡。在本章中，我们将探讨铁在促进细胞死亡中的作用以及相关的信号通路。
