Iron and Cell Death.

Iron is an essential micronutrient that supports cellular pathways such as DNA replication, metabolism, oxygen transport and oxidative phosphorylation via reduction-oxidation reactions. Nevertheless, in specific conditions, iron can be deleterious since it promotes different types of unprogrammed and programmed cell death, including apoptosis, necroptosis, and ferroptosis. In this chapter, we will address the role of iron in promoting cell death and the signaling pathways involved.