Altamura Sandro, Muckenthaler Martina U
Center for Translational Biomedical Iron Research, Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, Heidelberg, Germany.
Molecular Medicine Partnership Unit, Heidelberg, Germany.
Adv Exp Med Biol. 2025;1480:103-118. doi: 10.1007/978-3-031-92033-2_8.
Disorders of iron metabolism pose a global health challenge. Over the past two decades, novel regulators of systemic iron homeostasis have been identified that can be manipulated for therapeutic purposes. In this context, inbred and genetically modified mice have proven to be valuable tools enabling precise investigation of gene functions and testing of new pharmacological treatments that in some cases have reached the clinical stage. Here, we summarize the most recent discoveries on mechanisms regulating systemic iron homeostasis, with a specific focus on the role of murine models in advancing this research.
铁代谢紊乱对全球健康构成挑战。在过去二十年中，已鉴定出全身铁稳态的新型调节因子，这些调节因子可用于治疗目的的调控。在此背景下，近交系和转基因小鼠已被证明是有价值的工具，能够精确研究基因功能并测试一些已进入临床阶段的新药物治疗方法。在这里，我们总结了关于调节全身铁稳态机制的最新发现，特别关注小鼠模型在推进这项研究中的作用。
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