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NPJ Precis Oncol. 2024 Jul 26;8(1):158. doi: 10.1038/s41698-024-00656-0.
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Imaging with [Zr]Zr-DFO-SC16.56 anti-DLL3 antibody in patients with high-grade neuroendocrine tumours of the lung and prostate: a phase 1/2, first-in-human trial.[Zr]Zr-DFO-SC16.56 抗 DLL3 抗体在肺和前列腺高级别神经内分泌肿瘤患者中的成像:一项 1/2 期、首例人体试验。
Lancet Oncol. 2024 Aug;25(8):1015-1024. doi: 10.1016/S1470-2045(24)00249-3. Epub 2024 Jun 28.
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Types of Evidence Needed to Assess the Clinical Value of Diagnostic Imaging.评估诊断影像学临床价值所需的证据类型。
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癌症管理中基于证据、以结果为导向的医学影像研究的必要性。

The need for evidence-based, outcome-focused medical imaging research for cancer management.

作者信息

Wang Jiazheng, Hesketh Richard L, Gore John C, Brindle Kevin M

机构信息

Clinical & Technical Support, Philips Healthcare, Beijing, China.

Centre for Medical Imaging, University College London, 2nd Floor, Charles Bell House, 43-45 Foley Street, London, W1W 7TY, UK.

出版信息

Npj Imaging. 2025 Feb 3;3(1):6. doi: 10.1038/s44303-024-00067-7.

DOI:10.1038/s44303-024-00067-7
PMID:40604132
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12118759/
Abstract

Radiological imaging is essential in the diagnosis and management of cancer, but current clinical practice makes little use of the additional information available from advanced, multi-modal imaging techniques. A major factor holding back adoption is a lack of robust clinical evidence supporting the critical value of these techniques. We argue there remain compelling needs for better designs of clinical trials, imaging protocol standards, quantification methods, efficient translation pathways and patient engagement.

摘要

放射成像在癌症的诊断和管理中至关重要,但目前的临床实践很少利用先进的多模态成像技术所提供的额外信息。阻碍这些技术应用的一个主要因素是缺乏有力的临床证据来支持其关键价值。我们认为,仍然迫切需要更好地设计临床试验、成像协议标准、量化方法、高效的转化途径以及患者参与。