Kleynhans Janke, Gouws Christiaan A, Ebenhan Thomas
Department of Pharmaceutical and Pharmacological Sciences, Radiopharmaceutical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
Preclinical Imaging Facility, Nuclear Medicine Research Infrastructure NPC, Pretoria, South Africa.
Npj Imaging. 2025 May 28;3(1):22. doi: 10.1038/s44303-025-00082-2.
Improved PET/CT radiopharmaceuticals can better visualize and monitor tuberculosis and enable real-time pharmacological drug profiling in vivo. PET/CT imaging can therefore be used to study in animal models the changes in tissue pathology in tuberculosis infection, such as mycobacterial latency, tuberculoma formation, lung cavitation or calcification, and extrapulmonary disease. This Perspective aims to critically evaluate the current and future contribution and role of PET imaging in anti-tuberculosis drug development.
改进的正电子发射断层扫描/计算机断层扫描（PET/CT）放射性药物能够更好地可视化和监测结核病，并能在体内实现实时药理学药物分析。因此，PET/CT成像可用于在动物模型中研究结核病感染时组织病理学的变化，如分枝杆菌潜伏、结核瘤形成、肺空洞或钙化以及肺外疾病。本观点旨在批判性地评估PET成像在抗结核药物研发中的当前及未来贡献和作用。
