Silay Kamile, Selvi Oztorun Hande
Faculty of Medicine, Ankara Bilkent City Hospital, Department of Geriatrics, Ankara Yıldırım Beyazit University, Ankara, Türkiye.
BMC Geriatr. 2025 Jul 2;25(1):443. doi: 10.1186/s12877-025-06105-2.
Sarcopenic obesity (SO), the coexistence of low muscle mass and excess fat, is increasingly recognized in older adults. Its definition and clinical implications remain debated. This study evaluated SO using the European Society for Clinical Nutrition and Metabolism-European Association for the Study of Obesity (ESPEN-EASO) criteria and examined its associations with geriatric syndromes and metabolic risk factors.
We conducted a retrospective cross-sectional study of 364 hospitalized patients aged ≥ 65 years who underwent bioelectrical impedance analysis. Geriatric assessments included Activities of Daily Living (ADL), Instrumental ADL (IADL), Mini Nutritional Assessment-Short Form (MNA-SF), Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS), Clinical Frailty Scale (CFS), and handgrip strength. Mortality data were collected. Associations with SO were analyzed using univariate and multivariate logistic regression.
SO prevalence was 24.5%. Patients with SO had worse ADL, IADL, MNA-SF scores, and lower handgrip strength (all p < 0.01). Independent predictors of SO included older age (OR = 1.064, p = 0.002), female gender (OR = 3.574, p < 0.001), hypertension (OR = 2.094, p = 0.007), and diabetes mellitus (OR = 3.342, p < 0.001). The SO group had higher mortality (15.1% vs. 9.3%, p = 0.03). A geriatric model including frailty, MNA-SF (OR = 0.472, 95% CI: 0.306-0.727), and handgrip strength (OR = 0.741, 95% CI: 0.641-0.856) showed better model fit (Nagelkerke R² = 0.474) than the metabolic model (R² = 0.223).
SO is a distinct clinical condition linked to frailty, functional decline, and mortality. Geriatric factors show stronger associations than metabolic indicators, underscoring the importance of comprehensive geriatric screening in older adults.
Not applicable.
肌肉减少性肥胖（SO），即低肌肉量与脂肪过多并存的情况，在老年人中越来越受到关注。其定义和临床意义仍存在争议。本研究采用欧洲临床营养与代谢学会 - 欧洲肥胖研究协会（ESPEN - EASO）标准评估SO，并探讨其与老年综合征及代谢风险因素的关联。
我们对364名年龄≥65岁且接受生物电阻抗分析的住院患者进行了一项回顾性横断面研究。老年评估包括日常生活活动能力（ADL）、工具性日常生活活动能力（IADL）、简易营养评估简表（MNA - SF）、简易精神状态检查表（MMSE）、老年抑郁量表（GDS）、临床衰弱量表（CFS）和握力。收集了死亡率数据。使用单因素和多因素逻辑回归分析与SO的关联。
SO患病率为24.5%。SO患者的ADL、IADL、MNA - SF评分更差，握力更低（均p < 0.01）。SO的独立预测因素包括年龄较大（OR = 1.064，p = 即。002）、女性（OR = 3.574，p < 0即。（即1）、高血压（OR = 2.094，p = 即。007）和糖尿病（OR = 3.342，p < 0即。（即1）。SO组的死亡率更高（15.1%对9.3%，p = 即。03）。一个包括衰弱、MNA - SF（OR = 0.4⑦即，95% CI：0.306 - 0.727）和握力（OR = 0.741，95% CI：0.641 - 0.856）的老年模型显示出比代谢模型更好的模型拟合度（Nagelkerke R² = 0.474）（R² = 0.223）。
SO是一种与衰弱、功能衰退和死亡率相关联的独特临床状况。老年因素显示出比代谢指标更强的关联，强调了对老年人进行全面老年筛查的重要性。
不适用。
