Hu Qing, Liao Hua, Yu Haiyan
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, 3rd section, South Renmin Road, Chengdu, 610041, Sichuan, China.
Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.
BMC Public Health. 2025 Jul 2;25(1):2276. doi: 10.1186/s12889-025-23528-z.
Maternal hypertensive disorder seriously threatens maternal and neonatal health, contributing to high morbidity and mortality globally. Existing studies on its burden have limitations, like limited data periods or a lack of focus. There's a need for a comprehensive analysis.
This study utilized GBD 2021 data to systematically evaluate the global, regional, and national burden of Maternal hypertensive disorder from 1990 to 2021. It assessed deaths and Disability-Adjusted Life Years, explored temporal trends with linear regression, analyzed regional patterns via cluster analysis, identified burden change drivers using decomposition analysis, estimated achievable outcomes through frontier analysis, and predicted future trends with the Bayesian model for age-period-cohort for better public health planning.
From 1990 to 2021, the global age-standardized incidence, prevalence, mortality, and Disability-Adjusted Life Years rates of Maternal hypertensive disorder decreased to 227.96,44.42,0.48, and 31.29 per 100,000, respectively. Based on Bayesian model for the age-period-cohort projections, they will continue to decline to 2046. However, there were marked disparities. Low-Socio-Development Index regions had a heavier burden, and some regions like parts of Latin America & Caribbean saw an increase, while East Asia had a decrease. Aging, population growth, and epidemiological changes had different effects on the burden across regions.
This study suggests that targeted public health policies are essential. Low-income regions must enhance healthcare infrastructure and promote family planning, while high-income areas should focus on the aging maternal population. However, the study has limitations concerning data accuracy and model assumptions. Future research should strive to improve data quality and analytical models to better address maternal health disparities and enhance maternal health outcomes.
孕产妇高血压疾病严重威胁孕产妇和新生儿健康，在全球范围内导致高发病率和死亡率。现有关于其负担的研究存在局限性，如数据期有限或缺乏重点。需要进行全面分析。
本研究利用全球疾病负担研究（GBD）2021数据，系统评估了1990年至2021年全球、区域和国家层面的孕产妇高血压疾病负担。评估了死亡人数和伤残调整生命年，通过线性回归探讨时间趋势，通过聚类分析分析区域模式，使用分解分析确定负担变化驱动因素，通过前沿分析估计可实现的结果，并使用年龄-时期-队列贝叶斯模型预测未来趋势，以更好地进行公共卫生规划。
1990年至2021年，全球孕产妇高血压疾病的年龄标准化发病率、患病率、死亡率和伤残调整生命年率分别降至每10万人227.96、44.42、0.48和31.29。根据年龄-时期-队列贝叶斯模型预测，到2046年这些指标将继续下降。然而，存在明显差异。社会发展指数低的地区负担较重，拉丁美洲和加勒比部分地区等一些地区有所增加，而东亚地区则有所下降。老龄化、人口增长和流行病学变化对不同地区的负担产生了不同影响。
本研究表明，针对性的公共卫生政策至关重要。低收入地区必须加强医疗基础设施并推广计划生育，而高收入地区应关注老年孕产妇群体。然而，本研究在数据准确性和模型假设方面存在局限性。未来的研究应努力提高数据质量和分析模型，以更好地解决孕产妇健康差异问题并改善孕产妇健康结果。
